SCHEMBL5143422

CC(C)(C)[C@@H](CO)NS(=O)(=O)c1c(Cl)cc(Cl)cc1Cl.CC(C)(C)[C@@H](CO)NS(=O)(=O)c1cc(Cl)c(Cl)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1	P04150	7/20	0.39

▸	NR3C2	P08235	4/20	0.39

▸	PGR	P06401	3/20	0.39

▸	ALOX5AP	P20292	4/20	0.36

▸	FEN1	P39748	4/20	0.36

▸	ATM	Q13315	1/20	0.35

▸	ITGAV	P06756	1/20	0.35

▸	ACLY	P53396	1/20	0.34

▸	CNR1	P21554	1/20	0.34

▸	CNR2	P34972	1/20	0.34

▸	GUSB	P08236	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3178425	0.92	NR3C1 (0.44)	NR3C1NR3C2PGRALOX5APFEN1
SCHEMBL3186180	0.91	PGR (0.41)	NR3C1NR3C2PGRALOX5APFEN1
SCHEMBL3178938	0.74	NR3C1 (0.43)	NR3C1NR3C2PGRALOX5APFEN1
SCHEMBL6534445	0.74	NR3C1 (0.43)	NR3C1NR3C2PGRALOX5APFEN1
SCHEMBL3188196	0.73	RAB9A (0.50)	NR3C1CNR1
SCHEMBL3179889	0.71	MMP2 (0.50)	—
SCHEMBL3185176	0.70	ALOX5AP (0.41)	NR3C1NR3C2PGRALOX5APFEN1
SCHEMBL1169149	0.65	PSEN1 (0.60)	—
SCHEMBL21789195	0.65	ALOX5AP (0.37)	ALOX5APFEN1
SCHEMBL10882531	0.65	PGR (0.45)	NR3C1NR3C2PGRATMCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7166622-B2	Substituted phenylsulfonamide inhibitors of beta amyloid production	WYETH (US)	2007-01-23	—	—	US	claimed