Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143661 | 1.00 | NPSR1 (0.50) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL12213573 | 1.00 | NPSR1 (0.50) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL11600719 | 0.88 | NPSR1 (0.50) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL11494484 | 0.82 | NPSR1 (0.48) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL24793666 | 0.81 | NPSR1 (0.52) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL6570866 | 0.81 | NPSR1 (0.52) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL1127387 | 0.81 | NPSR1 (0.52) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL13713079 | 0.80 | NPSR1 (0.47) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL11753351 | 0.79 | NPSR1 (0.50) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 | |
| SCHEMBL10460625 | 0.79 | NPSR1 (0.50) | NPSR1ALDH1A1HCAR2LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116178438-A | Novel chiral phosphine-spiro phosphoramidite ligand and preparation and application thereof | 中国科学院大连化学物理研究所 | 2023-05-30 | — | — | CN | disclosed |
| US-7169953-B2 | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions | THE PENN STATE RESEARCH FOUNDATION (US) | 2007-01-30 | — | — | US | disclosed |
| US-7153809-B2 | For use as catalysts in asymmetric reactions, such as, hydrogenation, hydride transfer, allylic alkylation, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, olefin metathesis, hydrocarboxylation | THE PENN STATE RESEARCH FOUNDATION (US) | 2006-12-26 | — | — | US | disclosed |
| WO-2005117907-A2 | P-CHIRAL PHOSPHOLANES AND PHOSPHOCYCLIC COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYTIC REACTIONS | THE PENN STATE RESEARCH FOUNDATION (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20050119495-A1 | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions | THE PENN STATE RESEARCH FOUNDATION | 2005-06-02 | — | — | US | disclosed |
| US-20040229846-A1 | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions | THE PENN STATE RESEARCH FOUNDATION | 2004-11-18 | — | — | US | disclosed |
| US-20040186314-A1 | Process for the preparation of enantiomerically enriched n-acyl-beta-amino acid derivatives by enantioselective hydrogenation of the corresponding (z)-enamides | MALAN CHRISTOPHE GUILLAUME (CH) | 2004-09-23 | — | — | US | disclosed |
| EP-1421059-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED N-ACYL-BETA-AMINO ACID DERIVATIVES BY ENANTIOSELECTIVE HYDROGENATION OF THE CORRESPONDING (Z)-ENAMIDES | DOW GLOBAL TECHNOLOGIES INC. (US) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003016264-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED N-ACYL-BETA-AMINO ACID DERIVATIVES BY ENANTIOSELECTIVE HYDROGENATION OF THE CORRESPONDING (Z)-ENAMIDES | CHIROTECH TECHNOLOGY LIMITED (GB) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229846-A1 | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions | PNKP, PFKFB4, PFKFB3 | NPSR1 2550/4885ALDH1A1 1540/4885HCAR2 3698/4885 |
| US-20040186314-A1 | Process for the preparation of enantiomerically enriched n-acyl-beta-amino acid derivatives by enantioselective hydrogenation of the corresponding (z)-enamides | EEF1D, ADH5, HRH3 | NPSR1 292/4885ALDH1A1 1084/4885HCAR2 1308/4885 |
| US-20050119495-A1 | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions | PFKFB4, PFKFB3, PFKFB1 | NPSR1 2292/4885ALDH1A1 1175/4885HCAR2 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.