SCHEMBL514459

SCHEMBL514459

O=[C]COc1ccccc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.47
TDP1 Q9NUW8 2/20 0.47
DAO P14920 1/20 0.46
HPGD P15428 2/20 0.42
KDM4E B2RXH2 3/20 0.41
MRGPRX4 Q96LA9 1/20 0.41
LMNA P02545 1/20 0.41
FKBP1A P62942 1/20 0.41
KMT2A Q03164 4/20 0.40
MEN1 O00255 3/20 0.40
ALDH1A1 P00352 3/20 0.40
CYP1A2 P05177 2/20 0.40
CYP2D6 P10635 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
RECQL P46063 1/20 0.40
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40
ADRB2 P07550 1/20 0.40
CXCL8 P10145 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6298723 0.84 KDM4E (0.41) L3MBTL1TDP1HPGDKDM4ELMNA
SCHEMBL5534923 0.84 SLC6A2 (0.40) L3MBTL1TDP1DAOMRGPRX4
SCHEMBL27585808 0.81 GRM2 (0.34) L3MBTL1TDP1DAOMRGPRX4
SCHEMBL8065801 0.80 ADRA1D (0.36) DAO
SCHEMBL5539094 0.80 L3MBTL1 (0.53) L3MBTL1TDP1DAOKDM4EKMT2A
SCHEMBL31621296 0.79 KCNN4 (0.48) L3MBTL1TDP1DAOHPGDKDM4E
SCHEMBL28667032 0.79 L3MBTL1 (0.52) L3MBTL1TDP1DAOHPGDKDM4E
SCHEMBL4817251 0.79 MAPT (0.49) L3MBTL1TDP1DAOHPGDKDM4E
SCHEMBL3256218 0.79 KCNN4 (0.48) L3MBTL1TDP1DAOHPGDKDM4E
SCHEMBL98050 0.79 L3MBTL1 (0.56) L3MBTL1TDP1DAOKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116143678-A Conjugate linker, cell-binding molecule-drug conjugate containing the same, and preparation and application thereof 杭州多禧生物科技有限公司 2023-05-23 CN claimed
US-20230057350-A1 A CONJUGATE OF AN AMANITA TOXIN WITH BRANCHED LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-02-23 US claimed
CN-115443134-A Conjugates of cell binding molecules and camptothecin analogs 杭州多禧生物科技有限公司 2022-12-06 CN claimed
EP-3888691-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS Hangzhou Dac Biotech Co., Ltd. (CN) 2021-10-06 EP claimed
CN-113195487-A 2, 3-diaminosuccinyl conjugate linkers 杭州多禧生物科技有限公司 2021-07-30 CN claimed
US-20200215206-A1 SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF SUZHOU M-CONJ BIOTECH CO., LTD. (CN) 2020-07-09 US claimed
US-10322104-B2 Disulfur bridge linkers for conjugation of a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-06-18 US claimed
US-10293055-B2 Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-05-21 US claimed
US-10292961-B2 Disulfur bridge linkers for conjugation of a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-05-21 US claimed
EP-3319936-A2 BRIDGE LINKERS FOR CONJUGATION OF CELL-BINDING MOLECULES Suzhou M-conj Biotech Co., Ltd. (CN) 2018-05-16 EP claimed
US-20170209595-A1 DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE SUZHOU M-CONJ BIOTECH CO., LTD. (CN) 2017-07-27 US claimed
US-20170173176-A1 ACETYLENEDICARBOXYL LINKERS AND THEIR USES IN SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE SUZHOU M-CONJ BIOTECH CO., LTD. (CN) 2017-06-22 US claimed
US-20150314017-A1 DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE SUZHOU M-CONJ BIOTECH CO., LTD (CN) 2015-11-05 US claimed
EP-0675895-B1 ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER PF MEDICAMENT (FR) 1997-07-23 EP claimed
US-5643885-A Etoposide derivatives, process for preparing them, their use as a medicinal product and their use for the preparation of a medicinal product intended for anti-cancer treatment PIERRE FABRE MEDICAMENT (FR) 1997-07-01 US claimed
JP-H08504795-A 1996-05-21 JP claimed
EP-0675895-A1 ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER. FABRE PIERRE COSMETIQUE (FR) 1995-10-11 EP claimed
WO-1994014829-A1 ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER PIERRE FABRE MEDICAMENT (FR) 1994-07-07 WO claimed
WO-2024129931-A1 ALPHA-V BETA-6(ανβ6) INTEGRIN LIGANDS FOR EXTRAHEPATIC DELIVERY ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-20 WO disclosed
WO-1995034540-A1 BENZOHETEROCYCLIC DERIVATIVES USEFUL AS VASOPRESSIN OR OXYTOCIN MODULATORS OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1995-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10292961-B2 Disulfur bridge linkers for conjugation of a cell-binding molecule CD74, CD2, EPCAM L3MBTL1 757/4885TDP1 2250/4885DAO 787/4885
US-20230057350-A1 A CONJUGATE OF AN AMANITA TOXIN WITH BRANCHED LINKERS BTN3A1, ANTXR2, CLTA L3MBTL1 94/4885TDP1 3065/4885DAO 568/4885
US-20170173176-A1 ACETYLENEDICARBOXYL LINKERS AND THEIR USES IN SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE AADAC, EPCAM, DCLRE1A L3MBTL1 1920/4885TDP1 4027/4885DAO 934/4885
US-10322104-B2 Disulfur bridge linkers for conjugation of a cell-binding molecule CD74, CD2, EPCAM L3MBTL1 757/4885TDP1 2250/4885DAO 787/4885
US-20170209595-A1 DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE CD74, CD2, EPCAM L3MBTL1 757/4885TDP1 2250/4885DAO 787/4885
US-10293055-B2 Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule AADAC, EPCAM, DCLRE1A L3MBTL1 1920/4885TDP1 4027/4885DAO 934/4885
US-20200215206-A1 SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF SLC25A1, GCDH, FH L3MBTL1 1022/4885TDP1 3693/4885DAO 191/4885
US-20150314017-A1 DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE CD74, CD2, EPCAM L3MBTL1 757/4885TDP1 2250/4885DAO 787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.