SCHEMBL5144593

SCHEMBL5144593

N#Cc1cccc(-c2ccc[c]c2Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK4 Q9HAZ1 1/20 0.47
ADRA2C P18825 1/20 0.47
ENPP1 P22413 1/20 0.44
PTGDR2 Q9Y5Y4 1/20 0.41
PDK2 Q15119 1/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
HTT P42858 1/20 0.41
KMT2A Q03164 1/20 0.41
KCNA5 P22460 1/20 0.41
KCNH2 Q12809 1/20 0.41
XDH P47989 1/20 0.40
SLC22A12 Q96S37 1/20 0.40
MAOB P27338 2/20 0.40
CHEK1 O14757 1/20 0.40
EIF4E P06730 1/20 0.39
PGR P06401 1/20 0.39
IDO1 P14902 2/20 0.39
NOTUM Q6P988 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4277668 0.83 MMP3 (0.39) PDK2MAOBHDAC8
SCHEMBL5384403 0.78 ALOX5 (0.44) PDK2MEN1KMT2AMAOBNOTUM
SCHEMBL996127 0.77 ADRA2C (0.64) CLK4ADRA2CPDK2XDHSLC22A12
SCHEMBL28022368 0.76 ADRA2C (0.59) CLK4ADRA2CENPP1PTGDR2PDK2
SCHEMBL3097233 0.75 IKBKB (0.46) CLK4ADRA2CPTGDR2PDK2XDH
SCHEMBL6190375 0.75 ADRA2C (0.42) CLK4ADRA2CENPP1PTGDR2MEN1
SCHEMBL4275992 0.75 HSD17B1 (0.50) CLK4
SCHEMBL11514349 0.75 MAP4K4 (0.50) MEN1LMNAMAPTKMT2A
SCHEMBL2429097 0.75 TAAR1 (0.43) CLK4PDK2MEN1MAPTKMT2A
SCHEMBL20396135 0.74 ADRA2C (0.57) CLK4ADRA2CPDK2XDHSLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1581595-A4 OPTICAL MEMBERS AND POLYMERIZABLE COMPOSITIONS AND THIO COMPOUNDS FOR PRODUCING THEM FUJIFILM CORP (JP) 2007-03-21 EP disclosed
US-20060178457-A1 Optical members and polymerizable compositions and thio compounds for producing them FUJIFILM CORPORATION (JP) 2006-08-10 US disclosed
EP-1581595-A1 OPTICAL MEMBERS AND POLYMERIZABLE COMPOSITIONS AND THIO COMPOUNDS FOR PRODUCING THEM FUJI PHOTO FILM CO., LTD. (JP) 2005-10-05 EP disclosed
WO-2004061009-A1 OPTICAL MEMBERS AND POLYMERIZABLE COMPOSITIONS AND THIO COMPOUNDS FOR PRODUCING THEM FUJI PHOTO FILM CO., LTD. (JP) 2004-07-22 WO disclosed