Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.44 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.44 |
| ▸ | CHRNG | P07510 | 4/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.44 |
| ▸ | CHRND | Q07001 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27748869 | 0.70 | MAOB (0.47) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL1072701 | 0.67 | SLC6A2 (0.69) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 | |
| Bromide SCHEMBL13729160 | 0.66 | SLC6A2 (0.68) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL6811754 | 0.66 | ALDH1A1 (0.61) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL10728832 | 0.66 | SLC6A2 (0.68) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL11268568 | 0.66 | SLC6A2 (0.70) | SLC6A2SLC6A3CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL27647452 | 0.65 | MAOB (0.46) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL28360223 | 0.65 | SLC6A2 (0.67) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL11037118 | 0.65 | SLC6A2 (0.67) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL9796926 | 0.65 | SLC6A3 (0.60) | MAOBSLC6A2SLC6A3CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191431-A1 | 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation | WYETH (US) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191431-A1 | 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation | BACE1, BACE2, PSEN1 | MAOB 942/4885SLC6A2 4032/4885SLC6A3 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.