Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5143568 | 0.92 | MMP8 (0.55) | MMP8SLC1A3SLC1A2SLC1A1L3MBTL1 | |
| SCHEMBL5145270 | 0.87 | MMP8 (0.54) | MMP8SLC1A3SLC1A2SLC1A1L3MBTL1 | |
| SCHEMBL7420068 | 0.87 | MMP8 (0.54) | MMP8SLC1A3SLC1A2SLC1A1L3MBTL1 | |
| SCHEMBL27622664 | 0.87 | MMP8 (0.56) | MMP8SLC1A3SLC1A2SLC1A1L3MBTL1 | |
| SCHEMBL15016003 | 0.87 | MMP8 (0.56) | MMP8SLC1A3SLC1A2SLC1A1L3MBTL1 | |
| SCHEMBL6875049 | 0.86 | MME (0.46) | MMP8LMNAACEPPARGMEN1 | |
| SCHEMBL892960 | 0.84 | MMP8 (0.61) | MMP8SLC1A3SLC1A2SLC1A1L3MBTL1 | |
| SCHEMBL5085947 | 0.82 | MMP8 (0.55) | MMP8SLC1A3SLC1A2SLC1A1L3MBTL1 | |
| SCHEMBL7436297 | 0.81 | SLC1A3 (0.63) | SLC1A3SLC1A2SLC1A1HSD17B10CYP1A2 | |
| SCHEMBL3866544 | 0.81 | SLC1A3 (0.63) | SLC1A3SLC1A2SLC1A1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7301031-B2 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | BIOCATALYTICS, INC. (US) | 2007-11-27 | — | — | US | disclosed |
| US-7081535-B2 | Hydroxy-amino acids | BIOCATALYTICS, INC. (US) | 2006-07-25 | — | — | US | disclosed |
| US-20050192439-A1 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | CODEXIS, INC. | 2005-09-01 | — | — | US | disclosed |
| US-20050100993-A1 | Methods for producing hydroxy amino acids and derivatives thereof | BIOCATALYTICS, INC. | 2005-05-12 | — | — | US | disclosed |
| US-6833471-B2 | Contacting beta-ketodiester having ketone and two esters with a ketoreductase under conditions permitting reduction of ketone to alcohol, regioselectively hydrolyzing one of ester groups to acid, converting acid or ester to amine | BIOCATALYTICS, INC. | 2004-12-21 | — | — | US | disclosed |
| US-20040053377-A1 | Methods for producing hydroxy amino acids and derivatives thereof | CODEXIS, INC. | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053377-A1 | Methods for producing hydroxy amino acids and derivatives thereof | HMGCR, HSD17B12, BCKDK | MMP8 2298/4885SLC1A3 985/4885SLC1A2 1448/4885 |
| US-20050100993-A1 | Methods for producing hydroxy amino acids and derivatives thereof | ALDH7A1, BCKDK, HSD17B12 | MMP8 2240/4885SLC1A3 382/4885SLC1A2 466/4885 |
| US-20050192439-A1 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | ALDH7A1, BCKDK, ADH5 | MMP8 2236/4885SLC1A3 526/4885SLC1A2 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.