Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 5-Bromouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Bromouracil SCHEMBL639925 | 0.94 | KMT2A (0.39) | ALDH1A1LMNASMN1; SMN2KMT2ATDP1 | |
| SCHEMBL104627 | 0.82 | KMT2A (0.48) | ALDH1A1KMT2ATDP1KDM3B | |
| SCHEMBL101944 | 0.79 | LMNA (0.41) | LMNASMN1; SMN2 | |
| 5-Bromouracil SCHEMBL1079108 | 0.72 | MAPT (0.76) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| SCHEMBL9109566 | 0.69 | KMT2A (0.46) | ALDH1A1KMT2ATDP1KDM3B | |
| Fluorouracil SCHEMBL28636004 | 0.69 | LMNA (0.59) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| SCHEMBL7206108 | 0.69 | CYP3A4 (0.33) | LMNASMN1; SMN2 | |
| Adipic Acid SCHEMBL28687655 | 0.67 | LMNA (0.66) | ALDH1A1LMNAMAPTCYP19A1TSHR | |
| SCHEMBL28991875 | 0.67 | GAA (0.46) | LMNAMAPT | |
| Fluorouracil SCHEMBL20775915 | 0.67 | LMNA (0.70) | ALDH1A1LMNAMAPTCYP19A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007012807-A2 | DNA STRUCTURES | UNIVERSITY OF LEEDS (GB) | 2007-02-01 | — | — | WO | disclosed |