Urea

Urea

SCHEMBL5146646

NC(N)=O.NC(N)=O.NC(N)=O.c1ncncn1

nearest known ligand 0.50

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.50
ALDH1A1 P00352 1/20 0.50
OR51E2 Q9H255 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
HCAR2 Q8TDS4 1/20 0.38
ACHE P22303 1/20 0.36
ALOX15 P16050 1/20 0.33
BLM P54132 1/20 0.33
PMP22 Q01453 1/20 0.33
ADORA3 P0DMS8 1/20 0.32
TSHR P16473 1/20 0.32
MC4R P32245 1/20 0.32
ADRA1A P35348 1/20 0.32
MC3R P41968 1/20 0.32
HSP90AA1 P07900 1/20 0.32
LDHA P00338 1/20 0.31
LDHB P07195 1/20 0.31
F7 P08709 1/20 0.31
F3 P13726 1/20 0.31
SARM1 Q6SZW1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urea SCHEMBL2538456 1.00 LMNA (0.50) LMNAALDH1A1OR51E2TDP1HCAR2
Carbamic Acid SCHEMBL4048026 0.88 ACHE (0.54) LMNAALDH1A1OR51E2TDP1HCAR2
Carbamic Acid SCHEMBL7251118 0.88 ACHE (0.54) LMNAALDH1A1OR51E2TDP1HCAR2
Carbamic Acid SCHEMBL782968 0.88 ACHE (0.54) LMNAALDH1A1OR51E2TDP1HCAR2
Carbamic Acid SCHEMBL8573342 0.88 ACHE (0.54) LMNAALDH1A1OR51E2TDP1HCAR2
Pyrimidine SCHEMBL28421059 0.82 F7 (0.42) LMNAALDH1A1OR51E2TDP1HCAR2
Pyrimidine SCHEMBL374258 0.82 F7 (0.42) LMNAALDH1A1OR51E2TDP1HCAR2
Pyrimidine SCHEMBL28845102 0.79 F7 (0.41) LMNAALDH1A1OR51E2TDP1HCAR2
Bicarbonate SCHEMBL3158090 0.78 HCAR2 (0.47) HCAR2
Acrylamide SCHEMBL11610222 0.77 ALDH1A1 (0.65) LMNAALDH1A1HCAR2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1867638-A1 Procedure for the Conection of two Molecules via Diels-Alder Reactions with Inverse Electron Demand Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2007-12-19 EP claimed