Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.37 |
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2972171 | 0.88 | BRAF (0.35) | BRAFRAF1MEN1KMT2ACLK1 | |
| SCHEMBL5148335 | 0.84 | PDE3B (0.36) | NPC1RAB9AKMT2AMAPK1ALDH1A1 | |
| SCHEMBL5147429 | 0.83 | ADORA1 (0.37) | BRAFMEN1NPC1KMT2AABL1 | |
| SCHEMBL5147311 | 0.82 | LMNA (0.37) | KMT2ACLK1MAPK1ALDH1A1LMNA | |
| SCHEMBL5145850 | 0.81 | HSD17B1 (0.38) | BRAFRAF1ABL1MAPK1ALDH1A1 | |
| SCHEMBL5147313 | 0.79 | ALDH1A1 (0.35) | NPC1RAB9AABL1MAPK1ALDH1A1 | |
| SCHEMBL2975277 | 0.79 | KDR (0.38) | BRAFRAF1CLK1CACNA2D1ADORA1 | |
| SCHEMBL5149101 | 0.79 | RAF1 (0.37) | BRAFRAF1ABL1ADORA2AADORA1 | |
| SCHEMBL5147498 | 0.79 | ALDH1A1 (0.36) | NPC1RAB9AMAPK1ALDH1A1LMNA | |
| SCHEMBL5179687 | 0.78 | ADORA1 (0.37) | CLK1ALDH1A1ADORA2AADORA1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |