Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147302 | 0.88 | ALDH1A1 (0.36) | POLBLMNASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL2984250 | 0.88 | POLB (0.36) | POLBLMNASMN1; SMN2RAB9AAR | |
| SCHEMBL5147311 | 0.87 | LMNA (0.37) | LMNASMN1; SMN2ARALDH1A1KMT2A | |
| SCHEMBL5147509 | 0.84 | ALDH1A1 (0.38) | POLBLMNASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL5147345 | 0.83 | LMNA (0.37) | LMNASMN1; SMN2ARALDH1A1TSHR | |
| SCHEMBL5148410 | 0.82 | LMNA (0.39) | LMNASMN1; SMN2ARALDH1A1TSHR | |
| SCHEMBL2976991 | 0.76 | POLB (0.35) | POLBLMNASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL5147313 | 0.76 | ALDH1A1 (0.35) | LMNASMN1; SMN2RAB9AALDH1A1TSHR | |
| SCHEMBL5147455 | 0.75 | PLA2G7 (0.37) | LMNAARALDH1A1HTTUSP2 | |
| SCHEMBL2986071 | 0.75 | PDGFRB (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |