Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147458 | 0.90 | ALDH1A1 (0.35) | PSMD14NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL2976413 | 0.85 | CDK1 (0.35) | ALDH1A1CDK1KDRILKKDM4E | |
| SCHEMBL5149073 | 0.84 | ILK (0.35) | PSMD14NPC1RAB9AALDH1A1CDK1 | |
| SCHEMBL2984673 | 0.81 | ILK (0.35) | ALDH1A1CDK1KDRILKKDM4E | |
| SCHEMBL2985221 | 0.80 | CDK1 (0.35) | NPC1RAB9AALDH1A1LMNACDK1 | |
| SCHEMBL5146079 | 0.79 | ALDH1A1 (0.38) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL5149221 | 0.78 | ALDH1A1 (0.39) | NPC1RAB9AALDH1A1LMNAMEN1 | |
| SCHEMBL2980677 | 0.78 | SCN9A (0.45) | CDK1KDRILKIRAK4AURKA | |
| SCHEMBL5145889 | 0.77 | ALDH1A1 (0.35) | NPC1RAB9AALDH1A1LMNAMEN1 | |
| SCHEMBL5147360 | 0.77 | CYP2A6 (0.35) | NPC1RAB9AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |