Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 4/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2984673 | 0.85 | ILK (0.35) | ILKIRAK4CDK1KDRAURKA | |
| SCHEMBL5149156 | 0.84 | MERTK (0.35) | PLA2G7 | |
| SCHEMBL5147346 | 0.84 | PSMD14 (0.41) | ILKIRAK4CDK1KDRNPC1 | |
| SCHEMBL2980677 | 0.84 | SCN9A (0.45) | ILKIRAK4CDK1KDRAURKA | |
| SCHEMBL2976413 | 0.83 | CDK1 (0.35) | ILKIRAK4CDK1KDRALDH1A1 | |
| SCHEMBL2985221 | 0.80 | CDK1 (0.35) | ILKIRAK4CDK1KDRNPC1 | |
| SCHEMBL5147458 | 0.74 | ALDH1A1 (0.35) | NPC1RAB9APSMD14PLA2G7ALDH1A1 | |
| SCHEMBL2979975 | 0.73 | CDC7 (0.31) | KDR | |
| SCHEMBL2982366 | 0.69 | MERTK (0.34) | — | |
| SCHEMBL2985538 | 0.67 | SCN9A (0.42) | IRAK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |