Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | CASP7 | P55210 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147497 | 0.86 | AKT3 (0.41) | ALDH1A1LMNATSHRMAPK1HTT | |
| SCHEMBL2985174 | 0.85 | USP2 (0.32) | ALDH1A1LMNATSHRMAPK1HSD17B10 | |
| SCHEMBL5146079 | 0.84 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5147380 | 0.82 | ALDH1A1 (0.40) | ALDH1A1LMNATSHRMAPK1HTT | |
| SCHEMBL5147417 | 0.80 | ALDH1A1 (0.38) | ALDH1A1LMNATSHRMAPK1HTT | |
| SCHEMBL5147316 | 0.80 | PLA2G7 (0.39) | ALDH1A1LMNATSHRMAPK1HSD17B10 | |
| SCHEMBL5147495 | 0.80 | ALDH1A1 (0.36) | ALDH1A1LMNATSHRMAPK1HTT | |
| SCHEMBL5179917 | 0.79 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5147346 | 0.78 | PSMD14 (0.41) | ALDH1A1LMNATSHRMAPK1HTT | |
| SCHEMBL5145833 | 0.78 | ALDH1A1 (0.43) | ALDH1A1LMNATSHRMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |