Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147314 | 0.85 | DHODH (0.41) | GSK3BDHODH | |
| SCHEMBL5147414 | 0.83 | ALDH1A1 (0.38) | ALDH1A1CDK9HPGDDHODH | |
| SCHEMBL5149008 | 0.78 | DHODH (0.35) | KDM4EGSK3AGSK3BCDK5DYRK1A | |
| SCHEMBL5147511 | 0.76 | POLB (0.37) | SMN1; SMN2RAB9ANPC1KMT2ACYP1A2 | |
| SCHEMBL5147487 | 0.72 | ALOX15 (0.34) | ALDH1A1SMN1; SMN2MEN1KMT2ACDK9 | |
| SCHEMBL5147359 | 0.67 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL2989628 | 0.66 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL7471621 | 0.62 | MEN1 (0.59) | ALDH1A1SMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL7469184 | 0.62 | SYK (0.54) | ALDH1A1SMN1; SMN2RAB9AGAANPC1 | |
| SCHEMBL2975042 | 0.61 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2RAB9AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |