Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 6/20 | 0.33 |
| ▸ | CCND1 | P24385 | 6/20 | 0.33 |
| ▸ | CCND3 | P30281 | 6/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.33 |
| ▸ | CDK7 | P50613 | 5/20 | 0.33 |
| ▸ | CDK9 | P50750 | 5/20 | 0.33 |
| ▸ | CCNH | P51946 | 5/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.33 |
| ▸ | MMP3 | P08254 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147314 | 0.77 | DHODH (0.41) | MAPK8MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2980393 | 0.75 | MMP3 (0.35) | ALOX15ALDH1A1LMNASMN1; SMN2CDK4 | |
| SCHEMBL2986658 | 0.74 | BRAF (0.45) | ALOX15ALDH1A1LMNASMN1; SMN2MMP3 | |
| SCHEMBL2984187 | 0.73 | BRAF (0.43) | ALOX15ALDH1A1LMNASMN1; SMN2MMP3 | |
| SCHEMBL5147445 | 0.73 | AKT3 (0.40) | — | |
| SCHEMBL5147362 | 0.72 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2CDK9KMT2A | |
| SCHEMBL2988685 | 0.72 | ALOX15 (0.45) | ALOX15ALDH1A1LMNASMN1; SMN2MMP3 | |
| SCHEMBL5147389 | 0.72 | DHODH (0.34) | ALDH1A1LMNAMAPK8MAPK13MAPK12 | |
| SCHEMBL2986562 | 0.70 | HPGD (0.37) | ALOX15ALDH1A1LMNASMN1; SMN2MMP3 | |
| SCHEMBL5147411 | 0.69 | DHODH (0.34) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |