Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 5/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147314 | 0.83 | DHODH (0.41) | DHODHAKT3IDH1MAPK13MAPK12 | |
| SCHEMBL5147445 | 0.82 | AKT3 (0.40) | DHODHAKT3IDH1MAPK1 | |
| SCHEMBL5147362 | 0.80 | ALDH1A1 (0.43) | DHODHALDH1A1LMNA | |
| SCHEMBL5149008 | 0.75 | DHODH (0.35) | DHODHMAPK1 | |
| SCHEMBL5147414 | 0.73 | ALDH1A1 (0.38) | DHODHALDH1A1IDH1MAPK13MAPK12 | |
| SCHEMBL5147384 | 0.72 | ALDH1A1 (0.38) | AKT3ALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL5147511 | 0.72 | POLB (0.37) | DHODHLMNAIKBKB | |
| SCHEMBL5147487 | 0.72 | ALOX15 (0.34) | ALDH1A1LMNAMAPK13MAPK12MAPK11 | |
| SCHEMBL2977023 | 0.71 | AKT3 (0.35) | AKT3MAPK1IKBKB | |
| SCHEMBL2977020 | 0.71 | AKT3 (0.35) | AKT3MAPK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |