Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 7/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147314 | 0.85 | DHODH (0.41) | AKT3DHODHIDH1 | |
| SCHEMBL5147362 | 0.81 | ALDH1A1 (0.43) | DHODH | |
| SCHEMBL5149008 | 0.77 | DHODH (0.35) | DHODHMAPK1 | |
| SCHEMBL5147366 | 0.76 | IKBKB (0.34) | AKT3DHODH | |
| SCHEMBL5147414 | 0.74 | ALDH1A1 (0.38) | DHODHIDH1 | |
| SCHEMBL5147511 | 0.73 | POLB (0.37) | DHODH | |
| SCHEMBL5147487 | 0.73 | ALOX15 (0.34) | — | |
| SCHEMBL5147444 | 0.72 | AKT3 (0.43) | AKT3HTR7MAPK1 | |
| SCHEMBL2990318 | 0.71 | AKT3 (0.42) | AKT3HTR7MAPK1 | |
| SCHEMBL13154186 | 0.67 | IKBKB (0.44) | AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |