Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.34 |
| ▸ | CHUK | O15111 | 4/20 | 0.33 |
| ▸ | IKBKG | Q9Y6K9 | 4/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147511 | 0.86 | POLB (0.37) | IKBKBCHUKIKBKGDHODHAURKA | |
| SCHEMBL5147314 | 0.82 | DHODH (0.41) | IKBKBDHODHAKT3 | |
| SCHEMBL5147362 | 0.78 | ALDH1A1 (0.43) | DHODHMAPTCDK9 | |
| SCHEMBL5149008 | 0.76 | DHODH (0.35) | DHODHAURKAAURKBCDK2CDK1 | |
| SCHEMBL5147445 | 0.76 | AKT3 (0.40) | DHODHAKT3 | |
| SCHEMBL5147389 | 0.74 | DHODH (0.34) | IKBKBDHODHAKT3 | |
| SCHEMBL5147414 | 0.74 | ALDH1A1 (0.38) | DHODHAURKAAURKBCDK4CDK2 | |
| SCHEMBL5147363 | 0.71 | IKBKB (0.36) | IKBKBCHUKIKBKGAKT3AURKA | |
| SCHEMBL2984656 | 0.70 | MAPK3 (0.37) | IKBKBCHUKIKBKGAKT3MAPT | |
| SCHEMBL5147487 | 0.69 | ALOX15 (0.34) | CDK4CDK2CDK1CDK7CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |