Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147500 | 0.74 | ALDH1A1 (0.53) | ALDH1A1MAPTNPC1HPGDCES2 | |
| Trifluoroacetic Acid SCHEMBL5147753 | 0.72 | ALDH1A1 (0.47) | ALDH1A1MAPTNPC1HPGDCES2 | |
| SCHEMBL5147818 | 0.72 | LMNA (0.46) | ALDH1A1MAPTNPC1HPGDSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL27852892 | 0.68 | KMT2A (0.56) | ALDH1A1MAPTNPC1HPGDSMN1; SMN2 | |
| SCHEMBL1924959 | 0.67 | PTPN1 (0.61) | ALDH1A1MAPTNPC1HPGDCES2 | |
| SCHEMBL29668746 | 0.67 | CES1 (0.60) | ALDH1A1MAPTNPC1HPGDSMN1; SMN2 | |
| SCHEMBL361933 | 0.67 | CES1 (0.60) | ALDH1A1MAPTNPC1HPGDSMN1; SMN2 | |
| SCHEMBL29930913 | 0.65 | KMT2A (0.67) | ALDH1A1MAPTNPC1HPGDSMN1; SMN2 | |
| SCHEMBL513707 | 0.65 | KMT2A (0.67) | ALDH1A1MAPTNPC1HPGDSMN1; SMN2 | |
| SCHEMBL8512564 | 0.65 | CA2 (0.36) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112044-A1 | Thiadiazoline derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| EP-1671957-A1 | THIADIAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-06-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112044-A1 | Thiadiazoline derivative | TLK2, TLK1, BRWD1 | ALDH1A1 278/4885MAPT 4054/4885NPC1 3547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.