Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.49 |
| ▸ | MDM4 | O15151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5834057 | 0.82 | TSHR (0.62) | TSHRALDH1A1KMT2AHPGDL3MBTL1 | |
| SCHEMBL9754281 | 0.82 | TSHR (0.62) | TSHRALDH1A1KMT2AHPGDL3MBTL1 | |
| SCHEMBL23122282 | 0.81 | MAPT (0.63) | ALDH1A1KMT2AHPGDL3MBTL1MEN1 | |
| SCHEMBL6426547 | 0.81 | MAPT (0.63) | ALDH1A1KMT2AHPGDL3MBTL1MEN1 | |
| SCHEMBL11265966 | 0.81 | FPR2 (0.51) | ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL31618280 | 0.81 | MAPT (0.63) | ALDH1A1KMT2AHPGDL3MBTL1MEN1 | |
| SCHEMBL4184595 | 0.80 | TSHR (0.61) | TSHRALDH1A1KMT2AHPGDL3MBTL1 | |
| SCHEMBL14263838 | 0.80 | TSHR (0.66) | TSHRALDH1A1KMT2AHPGDL3MBTL1 | |
| SCHEMBL6289427 | 0.80 | TSHR (0.61) | TSHRALDH1A1KMT2AHPGDL3MBTL1 | |
| SCHEMBL4665022 | 0.80 | ALDH1A1 (0.62) | TSHRALDH1A1KMT2AHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710232-B2 | Imidazole derivatives used as TAFIa inhibitors | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2014-04-29 | — | — | US | disclosed |
| EP-1864979-A1 | Imidazole-derivatives as TAFAIa-inhibitors | Sanofi-Aventis Deutschland GmbH (DE) | 2007-12-12 | — | — | EP | disclosed |
| US-20070129341-A1 | IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-06-07 | — | — | US | disclosed |
| EP-1740569-A1 | IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105781-A1 | IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129341-A1 | IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS | TFPI, TFPI2, SERPINC1 | TSHR 846/4885ALDH1A1 1472/4885KMT2A 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.