Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2976063 | 0.91 | PTGS1 (0.41) | PTGS1MAPTHPGDLMNAALDH1A1 | |
| SCHEMBL2985695 | 0.74 | HPGD (0.34) | MAPTHPGDLMNAALDH1A1GAA | |
| SCHEMBL2988533 | 0.69 | SIGMAR1 (0.45) | L3MBTL1 | |
| SCHEMBL8306828 | 0.69 | ALDH1A1 (0.47) | PTGS1MAPTHPGDLMNAALDH1A1 | |
| SCHEMBL27555980 | 0.68 | MEN1 (0.31) | ALDH1A1 | |
| SCHEMBL18723898 | 0.66 | TMEM97 (0.36) | MAPTHPGDLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL10787556 | 0.66 | CA2 (0.52) | PTGS1MAPTALDH1A1GAATAAR1 | |
| SCHEMBL28468260 | 0.65 | PTGS1 (0.38) | PTGS1MAPTHPGDLMNAALDH1A1 | |
| SCHEMBL8304165 | 0.65 | MAPT (0.40) | PTGS1MAPTHPGDLMNAALDH1A1 | |
| SCHEMBL24938229 | 0.65 | TAAR1 (0.40) | PTGS1MAPTHPGDLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |