Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ARNT | P27540 | 4/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689714 | 0.84 | ARNT (0.38) | ALDH1A1MAPTARNTEPAS1TSHR | |
| SCHEMBL9090596 | 0.77 | EPAS1 (0.34) | ALDH1A1MAPTARNTEPAS1HSD17B10 | |
| SCHEMBL3748576 | 0.74 | MAPT (0.48) | ALDH1A1MAPTTSHRTDP1MEN1 | |
| SCHEMBL3293261 | 0.73 | MEN1 (0.58) | ALDH1A1MAPTTSHRTDP1HSD17B10 | |
| SCHEMBL3663992 | 0.72 | ALDH1A1 (0.37) | ALDH1A1MAPTTSHRTDP1MEN1 | |
| SCHEMBL29702010 | 0.71 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL7514813 | 0.71 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL10816542 | 0.70 | TSHR (0.39) | ALDH1A1TSHRTDP1HSD17B10CYP3A4 | |
| SCHEMBL8688617 | 0.70 | TDP1 (0.46) | ALDH1A1MAPTTSHRTDP1HSD17B10 | |
| SCHEMBL8693683 | 0.69 | SMN1; SMN2 (0.41) | ALDH1A1MAPTMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220740-B2 | 1,4-diazabicyclo[3.2.2]nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-05-22 | — | — | US | disclosed |
| EP-1289988-B1 | 1,4-DIAZABICYCLO 3.2.2]NONABENZOXAZOLE, -BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SYNTHELABO (FR) | 2004-05-19 | — | — | EP | disclosed |
| US-20030153574-A1 | 1,4-diazabicyclo[3.2.2]nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2003-08-14 | — | — | US | disclosed |
| EP-1289988-A1 | 1,4-DIAZABICYCLO 3.2.2]NONABENZOXAZOLE, -BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001092261-A1 | 1,4-DIAZABICYCLO[3.2.2]NONABENZOXAZOLE, -BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-SYNTHELABO (FR) | 2001-12-06 | — | — | WO | disclosed |
| US-5753595-A | Herbicidal 3-(substituted benzoxazol-7-yl) and 3-(Substituted benzothiazol-7-yl)-1-substituted-6-trifluoromethyl-2 4-(1h 3h)pyrimidinediones | FMC CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1997008170-A1 | HERBICIDAL 3-(SUBSTITUTED BENZOXAZOL-7-YL) AND 3-(SUBSTITUTED BENZOTHIAZOL-7-YL)-1-SUBSTITUTED-6-TRIFLUOROMETHYL-2,4-(1H,3H)PYRIMIDINEDIONES | FMC CORPORATION (US) | 1997-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153574-A1 | 1,4-diazabicyclo[3.2.2]nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof | IL4I1, MT-CO1, CBR1 | ALDH1A1 170/4885MAPT 4650/4885ARNT 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.