Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946083 | 0.86 | CHRNA7 (0.76) | CHRNA7TSHRCASP1CYP2D6CYP1A2 | |
| SCHEMBL12300196 | 0.78 | CHRNA7 (0.64) | CHRNA7CYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL13946082 | 0.74 | CHRNA7 (0.59) | CHRNA7TSHRCASP1HRH3EGFR | |
| SCHEMBL8108453 | 0.73 | CYP2D6 (0.63) | CHRNA7CYP2D6KDM4EALDH1A1GAA | |
| SCHEMBL6943669 | 0.73 | CYP2D6 (0.63) | CHRNA7CYP2D6KDM4EALDH1A1GAA | |
| SCHEMBL10268675 | 0.73 | CHRNA7 (0.57) | CHRNA7CYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL1114221 | 0.72 | — | — | |
| SCHEMBL19459064 | 0.72 | CHRNA7 (0.56) | CHRNA7CYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL18843843 | 0.70 | CHRNA7 (0.54) | CHRNA7CYP2D6CYP1A2CYP3A4KDM4E | |
| SCHEMBL19459142 | 0.69 | CHRNA7 (0.52) | CHRNA7CYP2D6KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12202840-B2 | Compounds for the treatment or alleviation of disorders associated with Tau aggregates | AC IMMUNE SA (CH) | 2025-01-21 | — | — | US | disclosed |
| CN-112313230-B | Novel compounds for the treatment, alleviation or prevention of conditions associated with Tau aggregate | AC免疫有限公司 | 2024-03-15 | — | — | CN | disclosed |
| EP-3802528-B1 | NOVEL COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES | AC IMMUNE SA (CH) | 2022-07-06 | — | — | EP | disclosed |
| EP-3802528-B1 | NOVEL COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES | AC IMMUNE SA (CH) | 2022-07-06 | — | — | EP | disclosed |
| US-20210214371-A1 | Novel Compounds for the Treatment, Alleviation or Prevention of Disorders Associated with Tau Aggregates | AC IMMUNE SA (CH) | 2021-07-15 | — | — | US | disclosed |
| US-20210214371-A1 | Novel Compounds for the Treatment, Alleviation or Prevention of Disorders Associated with Tau Aggregates | AC IMMUNE SA (CH) | 2021-07-15 | — | — | US | disclosed |
| EP-3802528-A1 | NOVEL COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES | AC Immune SA (CH) | 2021-04-14 | — | — | EP | disclosed |
| CN-112313230-A | Novel compounds for treating, alleviating or preventing conditions associated with Tau aggregates | AC免疫有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019233745-A1 | NOVEL COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES | AC IMMUNE SA (CH) | 2019-12-12 | — | — | WO | disclosed |
| WO-2019233745-A1 | NOVEL COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES | AC IMMUNE SA (CH) | 2019-12-12 | — | — | WO | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090012071-A1 | 4-SUBSTITUTED-1H-ISOTHIAZOLO[5,4-B][1,4]OXAZINO[2,3,4-IJ]QUINOLINE-7,8(2H,9H)-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2009-01-08 | — | — | US | disclosed |
| WO-2007071840-A2 | COMPOUNDS BASED ON FOUR AROMATIC RINGS, PREPARATION AND USES THEREOF | CEREP (FR) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12202840-B2 | Compounds for the treatment or alleviation of disorders associated with Tau aggregates | MAPT, MAP1LC3A, TUBB3 | CHRNA7 449/4885TSHR 4275/4885CASP1 3180/4885 |
| US-20210214371-A1 | Novel Compounds for the Treatment, Alleviation or Prevention of Disorders Associated with Tau Aggregates | MAPT, MAP1LC3A, MAP1LC3B | CHRNA7 377/4885TSHR 4332/4885CASP1 2848/4885 |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | CHRNA7 4853/4885TSHR 1650/4885CASP1 984/4885 |
| US-20090012071-A1 | 4-SUBSTITUTED-1H-ISOTHIAZOLO[5,4-B][1,4]OXAZINO[2,3,4-IJ]QUINOLINE-7,8(2H,9H)-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | TOP1, TOP2B, TOP2A | CHRNA7 2510/4885TSHR 4685/4885CASP1 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.