SCHEMBL515098

SCHEMBL515098

CS(=O)(=O)c1ccccc1C(F)(F)F

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.56
MEN1 O00255 2/20 0.56
SLC22A12 Q96S37 11/20 0.50
HSD11B1 P28845 2/20 0.50
ALDH1A1 P00352 1/20 0.45
CYP2C9 P11712 1/20 0.44
SLC22A6 Q4U2R8 1/20 0.44
SLC22A8 Q8TCC7 1/20 0.44
SLC22A11 Q9NSA0 1/20 0.44
KAT6A Q92794 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7809492 0.82 HSD11B1 (0.45) KMT2AMEN1HSD11B1ALDH1A1
SCHEMBL3625928 0.82 MEN1 (0.60) KMT2AMEN1SLC22A12HSD11B1ALDH1A1
SCHEMBL29874131 0.82 MEN1 (0.60) KMT2AMEN1SLC22A12HSD11B1ALDH1A1
SCHEMBL24108707 0.82 MEN1 (0.43) KMT2AMEN1SLC22A12HSD11B1
SCHEMBL856017 0.81 KMT2A (0.55) KMT2AMEN1SLC22A12HSD11B1ALDH1A1
SCHEMBL23665026 0.80 MEN1 (0.42) KMT2AMEN1SLC22A12HSD11B1
SCHEMBL11217498 0.80 NR1H2 (0.43) KMT2AMEN1SLC22A12HSD11B1
SCHEMBL1516275 0.80 MEN1 (0.58) KMT2AMEN1SLC22A12HSD11B1ALDH1A1
SCHEMBL27993982 0.80 MEN1 (0.58) KMT2AMEN1SLC22A12HSD11B1ALDH1A1
SCHEMBL10292998 0.79 KMT2A (0.53) KMT2AMEN1SLC22A12HSD11B1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102321069-B Preparation method of 2-trifluoromethylthioxanthone JINAN FUCHUANG MEDICAL TECHNOLOGY CO LTD 2013-03-20 CN claimed
CN-102321069-A Preparation method of 2-trifluoromethylthioxanthone JINAN FUCHUANG MEDICAL TECHNOLOGY CO LTD 2012-01-18 CN claimed
EP-1718605-B1 PROCESSES FOR THE PREPARATION OF ARYL-AND HETEROARYL-ALKYLSULFONYL HALIDES WYETH CORP (US) 2009-06-17 EP claimed
WO-2023210623-A1 HALOALKYL SULFONE ANILIDE COMPOUND AND HERBICIDE CONTAINING SAME 株式会社エス・ディー・エス バイオテック 2023-11-02 WO disclosed
WO-2020247054-A1 COMPOUNDS, CONJUGATES, AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES AND USES THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2020-12-10 WO disclosed
EP-2598511-B1 NOVEL STABLE AND HIGHLY TUNABLE METATHESIS CATALYSTS ECOLE NAT SUPERIEURE DE CHIMIE DE RENNES (FR) 2018-07-04 EP disclosed
CN-108026610-A Method for separating americium from liquid radioactive substances and separating americium from rare earth elements 俄罗斯国家原子能公司 2018-05-11 CN disclosed
US-9856254-B2 Alkoxy substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY (US) 2018-01-02 US disclosed
US-9694002-B2 Substituted benzamides and methods of use thereof GENENTECH, INC. (US) 2017-07-04 US disclosed
WO-2017103188-A1 THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2017-06-22 WO disclosed
US-20170087136-A1 SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2017-03-30 US disclosed
US-7214698-B2 Beta-agonists, processes for preparing them and their use as pharmaceutical compositions BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2007-05-08 US disclosed
US-20070099955-A1 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS AVENTIS PHARMACEUTICALS INC. (US) 2007-05-03 US disclosed
US-20070078146-A1 Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma PHARMACIA CORPORATION 2007-04-05 US disclosed
US-20070060754-A1 Alkoxy substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2007-03-15 US disclosed
US-20070060754-A1 Alkoxy substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2007-03-15 US disclosed
US-7186834-B2 Substituted iminoazines BAYER AKTIENGESELLSCHAFT (DE) 2007-03-06 US disclosed
US-7186834-B2 Substituted iminoazines BAYER AKTIENGESELLSCHAFT (DE) 2007-03-06 US disclosed
CN-1178906-C N-hydroxyformamide derivatives as inhibitors of matrix metalloproteinases ���Ͽع����޹�˾ 2004-12-08 CN disclosed
CN-1261876-A N-hydroxyformamide derivatives as inhibitors of matrix metalloproteinases ABBOTT LAB (US) 2000-08-02 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070060754-A1 Alkoxy substituted imidazoquinolines IL2, IFNG, IRF3 KMT2A 2789/4885MEN1 3720/4885SLC22A12 4775/4885
US-20070099955-A1 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS DRD3, DRD2, DRD4 KMT2A 2239/4885MEN1 4213/4885SLC22A12 1961/4885
US-20070078146-A1 Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma MAPK1, MAPK3, MAPK4 KMT2A 1449/4885MEN1 3032/4885SLC22A12 4618/4885
US-20170087136-A1 SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF C1R, SRR, PNISR KMT2A 323/4885MEN1 2716/4885SLC22A12 848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.