Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 3/20 | 0.49 |
| ▸ | RXRB | P28702 | 3/20 | 0.49 |
| ▸ | RXRG | P48443 | 3/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575044 | 0.85 | GABRP (0.61) | TSHRABCC4LMNAGAAPTGS1 | |
| Hydrochloric Acid SCHEMBL7020108 | 0.84 | GABRP (0.59) | TSHRABCC4LMNAGAAPTGS1 | |
| SCHEMBL4037637 | 0.80 | TBXAS1 (0.50) | TSHRSMN1; SMN2RXRARXRBRXRG | |
| SCHEMBL16726559 | 0.79 | P4HTM (0.74) | TSHRABCC4LMNAGAAPTGS1 | |
| SCHEMBL18427891 | 0.79 | LMNA (0.86) | TSHRABCC4LMNAGAAPTGS1 | |
| SCHEMBL68027 | 0.79 | LMNA (0.86) | TSHRABCC4LMNAGAAPTGS1 | |
| SCHEMBL30461983 | 0.78 | MKNK1 (0.56) | TSHRSMN1; SMN2IDO1WNT3A | |
| SCHEMBL10093227 | 0.78 | MKNK1 (0.56) | TSHRSMN1; SMN2IDO1WNT3A | |
| SCHEMBL10228775 | 0.77 | ABCC4 (0.69) | TSHRABCC4LMNAGAAPTGS1 | |
| SCHEMBL12302553 | 0.77 | WNT3A (0.65) | TSHRABCC4LMNAGAAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211578-B2 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity | SANOFI-AVENTIS (FR) | 2007-05-01 | — | — | US | disclosed |
| US-20050004132-A1 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity | SANOFI-AVENTIS (FR) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004132-A1 | Nitrogenous tetrahydropyridyl-alkyl-heterocycles with tnf activity | TNF, TNFRSF1A, NFKBIA | TSHR 3046/4885ABCC4 2792/4885LMNA 3216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.