SCHEMBL5151365

SCHEMBL5151365

Cc1cc(C(=O)C(F)(F)F)ccc1NC(=O)OC(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCC9 O60706 2/20 0.44
ABCC8 Q09428 2/20 0.44
KCNJ11 Q14654 2/20 0.44
KCNJ8 Q15842 2/20 0.44
CYP17A1 P05093 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.42
RXFP1 Q9HBX9 1/20 0.41
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41
TAS1R2 Q8TE23 1/20 0.41
GABRB1 P18505 1/20 0.40
GABRB2 P47870 1/20 0.40
MLYCD O95822 3/20 0.40
ACHE P22303 1/20 0.40
CISD2 Q8N5K1 1/20 0.40
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA9 Q16790 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6240779 0.86 ABCC9 (0.43) ABCC9ABCC8KCNJ11KCNJ8CYP17A1
SCHEMBL628865 0.84 MAPT (0.46) ABCC9ABCC8KCNJ11KCNJ8CYP17A1
SCHEMBL30587156 0.84 MAPT (0.46) ABCC9ABCC8KCNJ11KCNJ8CYP17A1
SCHEMBL11959276 0.83 LCK (0.49) CYP17A1SMN1; SMN2TAS1R3TAS1R1TAS1R2
SCHEMBL29803307 0.81 RXFP1 (0.55) SMN1; SMN2RXFP1CISD2CA12CA1
SCHEMBL7667607 0.81 RXFP1 (0.55) SMN1; SMN2RXFP1CISD2CA12CA1
SCHEMBL8297312 0.81 SMN1; SMN2 (0.63) SMN1; SMN2TAS1R3TAS1R1TAS1R2CISD2
SCHEMBL6242548 0.80 ABCC9 (0.42) ABCC9ABCC8KCNJ11KCNJ8CYP17A1
SCHEMBL8292291 0.80 KCNQ4 (0.48) CYP17A1SMN1; SMN2CISD2CA12CA1
SCHEMBL6238138 0.78 NPC1 (0.43) CYP17A1SMN1; SMN2RXFP1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070043011-A1 Substituted benzanilide compound and noxious organism controlling agent MITSUBISHI TANABE PHARMA CORPORATION (JP) 2007-02-22 US disclosed
EP-1671941-A1 SUBSTITUTED BENZANILIDE COMPOUND AND PEST CONTROL AGENT Nissan Chemical Industries, Ltd. (JP) 2006-06-21 EP disclosed
US-20050250822-A1 Substituted benzanilide compound and noxious organism controlling agent NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2005-11-10 US disclosed
EP-1538138-A1 SUBSTITUTED BENZANILIDE COMPOUND AND PEST CONTROL AGENT NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 2005-06-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070043011-A1 Substituted benzanilide compound and noxious organism controlling agent L3MBTL1, L3MBTL3, L3MBTL4 ABCC9 1758/4885ABCC8 1096/4885KCNJ11 1214/4885
US-20050250822-A1 Substituted benzanilide compound and noxious organism controlling agent GCN1, L3MBTL3, L3MBTL4 ABCC9 1010/4885ABCC8 947/4885KCNJ11 1324/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.