SCHEMBL515201

SCHEMBL515201

CCc1cc(Br)ccc1I

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.40
HPGD P15428 2/20 0.40
LMNA P02545 1/20 0.40
TSHR P16473 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
POLB P06746 1/20 0.36
MAPK1 P28482 1/20 0.35
PRNP P04156 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
PPARG P37231 1/20 0.34
HIF1A Q16665 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
NR2E3 Q9Y5X4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31088263 1.00 SMN1; SMN2 (0.40) SMN1; SMN2HPGDLMNATSHRL3MBTL1
SCHEMBL30906634 0.82 BACE1 (0.40) SMN1; SMN2HPGDLMNATSHRL3MBTL1
SCHEMBL868296 0.82 BACE1 (0.40) SMN1; SMN2HPGDLMNATSHRL3MBTL1
Alcohol SCHEMBL5043640 0.81 PTGDR2 (0.41) SMN1; SMN2HPGDLMNATSHRALDH1A1
SCHEMBL17376656 0.79 TYR (0.39) SMN1; SMN2LMNATSHRL3MBTL1POLB
SCHEMBL30087221 0.79 CYP2A6 (0.32) HPGDTSHRL3MBTL1ALDH1A1MAPK1
SCHEMBL2556376 0.79 CYP2A6 (0.32) HPGDTSHRL3MBTL1ALDH1A1MAPK1
SCHEMBL7787482 0.78 GABRA1 (0.44) SMN1; SMN2HPGDLMNATSHRL3MBTL1
SCHEMBL134773 0.78 CCR5 (0.48) SMN1; SMN2HPGDLMNAL3MBTL1ALDH1A1
SCHEMBL12097459 0.77 CCR5 (0.31) TSHRPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 179 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4676476-A1 INHIBITORS OF TDP-43 AND TAU AGGREGATION Aquinnah Pharmaceuticals, Inc. (US) 2026-01-14 EP disclosed
US-12522569-B2 Substituted benzimidazole derivative and use thereof CHENGDU FANXI BIOPHARMA CO., LTD. (CN) 2026-01-13 US disclosed
EP-3730590-B1 LIQUID CRYSTAL MEDIA WITH HOMEOTROPIC ALIGNMENT MERCK PATENT GMBH (DE) 2025-12-24 EP disclosed
EP-4592308-A1 CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-07-30 EP disclosed
WO-2024187126-A1 INHIBITORS OF TDP-43 AND TAU AGGREGATION AQUINNAH PHARMACEUTICALS, INC. (US) 2024-09-12 WO disclosed
US-20240279550-A1 REACTIVE MESOGENS MERCK PATENT GMBH (DE) 2024-08-22 US disclosed
CN-109943349-B Liquid-crystalline medium with homeotropic alignment 默克专利股份有限公司 2024-07-05 CN disclosed
WO-2024101402-A1 PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS 中外製薬株式会社 2024-05-16 WO disclosed
CN-113912547-B Substituted benzene imidazole derivative and application thereof 成都凡诺西生物医药科技有限公司 2024-04-30 CN disclosed
EP-4334408-A1 REACTIVE MESOGENS Merck Patent GmbH (DE) 2024-03-13 EP disclosed
EP-2032548-A1 THIAZOLE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2009-03-11 EP disclosed
EP-1971582-A1 MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS Brystol-Myers Squibb Company (US) 2008-09-24 EP disclosed
WO-2008096218-A1 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER PFIZER INC. (US) 2008-08-14 WO disclosed
WO-2008079836-A2 MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-07-03 WO disclosed
WO-2007137962-A1 THIAZOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2007-12-06 WO disclosed
US-20070281979-A1 Fructose-1,6-bisphosphatase (FBPase) inhibitors, such as N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]3(difluoromethoxy)benzenesulfonamide, used as antidiabetic agents HOFFMANN-LA ROCHE INC. 2007-12-06 US disclosed
US-20070208054-A1 MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS BRISTOL-MYERS SQUIBB COMPANY 2007-09-06 US disclosed
WO-2007076431-A1 MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-07-05 WO disclosed
US-6673267-B2 EXHIBING HIGH REFRACTIVE INDEX ANISOTROPY; PHOTOSTABILITY; USEFUL IN PRODUCING COLORED FILMS, DISPLAYS, OPTICAL RECORDING MATERIALS, OPTICAL COMPENSATORS, POLARIZERS, REFLECTOR PLATES, AND SCATTERING PLATES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-01-06 US disclosed
US-20020006479-A1 Phenylacetylene compound, liquid crystal composition, polymer, optically anisotropic product, and liquid crystal or optical element SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240279550-A1 REACTIVE MESOGENS MCHR1, MCHR2, OPRM1 SMN1; SMN2 2929/4885HPGD 1196/4885LMNA 3584/4885
US-20070281979-A1 Fructose-1,6-bisphosphatase (FBPase) inhibitors, such as N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]3(difluoromethoxy)benzenesulfonamide, used as antidiabetic agents FBP1, PFKFB1, PFKFB3 SMN1; SMN2 3284/4885HPGD 2514/4885LMNA 4559/4885
US-20070208054-A1 MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS F12, F7, F2 SMN1; SMN2 3845/4885HPGD 3525/4885LMNA 217/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.