Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7546508 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL8632700 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL6557773 | 0.72 | ADRA2C (0.34) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| Hydrochloric Acid SCHEMBL8632372 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL18663191 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL5695988 | 0.69 | CASP3 (0.32) | PTGS2 | |
| Hydrochloric Acid SCHEMBL6904002 | 0.68 | NPC1 (0.42) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL6902904 | 0.68 | KDM4E (0.33) | — | |
| Hydrochloric Acid SCHEMBL6902608 | 0.68 | ALDH1A1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL6286843 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007003378-A2 | CATALYST | BOREALIS TECHNOLOGY OY (FI) | 2007-01-11 | — | — | WO | disclosed |
| EP-1739103-A1 | Catalyst | Borealis Technology Oy (FI) | 2007-01-03 | — | — | EP | disclosed |