Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6899139 | 0.90 | SYK (0.40) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6904743 | 0.88 | ALDH1A1 (0.37) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6902388 | 0.87 | NPC1 (0.36) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6898055 | 0.87 | NPC1 (0.36) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6904019 | 0.87 | ALDH1A1 (0.36) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6904521 | 0.85 | DHFR (0.39) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6903467 | 0.85 | GPR88 (0.38) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6902718 | 0.83 | ALDH1A1 (0.39) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6904678 | 0.83 | ALDH1A1 (0.33) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL6903366 | 0.83 | BRS3 (0.36) | NPC1ALDH1A1MAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |