SCHEMBL5153405

SCHEMBL5153405

Cc1ccccc1-c1[c]c(-c2ccccc2C)ccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.43
ACHE P22303 1/20 0.43
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
CYP3A4 P08684 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CYP2A6 P11509 2/20 0.38
CYP1A2 P05177 1/20 0.38
ALDH1A1 P00352 3/20 0.37
MYC P01106 1/20 0.36
GAA P10253 1/20 0.36
IDO1 P14902 1/20 0.36
METAP2 P50579 1/20 0.36
HTR7 P34969 2/20 0.36
CA1 P00915 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL336967 0.89 TSHR (0.38) TSHRACHENPC1RAB9ASMN1; SMN2
SCHEMBL28461076 0.85 ALDH1A1 (0.39) TSHRACHENPC1RAB9ASMN1; SMN2
SCHEMBL712397 0.76 ACHE (0.39) TSHRACHENPC1RAB9ASMN1; SMN2
SCHEMBL981109 0.76 TSHR (0.39) TSHRACHENPC1RAB9ASMN1; SMN2
SCHEMBL8125766 0.75 TRPA1 (0.38) TSHRACHESMN1; SMN2CYP2A6CYP1A2
SCHEMBL598761 0.74 TSHR (0.53) TSHRACHENPC1RAB9ASMN1; SMN2
SCHEMBL197690 0.74 ACHE (0.64) TSHRACHENPC1RAB9ASMN1; SMN2
SCHEMBL30169568 0.74 ACHE (0.64) TSHRACHENPC1RAB9ASMN1; SMN2
SCHEMBL30354037 0.74 ACHE (0.64) TSHRACHENPC1RAB9ASMN1; SMN2
SCHEMBL284410 0.74 TSHR (0.47) TSHRACHENPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1856164-A1 SUPPORTED OLEFIN POLYMERIZATION CATALYSTS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-11-21 EP disclosed
EP-1379562-B1 SUPPORTED OLEFIN POLYMERIZATION CATALYSTS DU PONT (US) 2007-08-29 EP disclosed
WO-2006094302-A1 SUPPORTED OLEFIN POLYMERIZATION CATALYSTS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-09-08 WO disclosed
US-20060199727-A1 Supported olefin polymerization catalysts E. I. DU PONT DE NEMOURS AND COMPANY 2006-09-07 US disclosed
US-6900153-B2 Supported olefin polymerization catalysts E.I. DU PONT DE NEMOURS AND COMPANY (US) 2005-05-31 US disclosed
US-20020187892-A1 Supported olefin polymerization catalysts E. I. DU PONT DE NEMOURS AND COMPANY 2002-12-12 US disclosed