Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507740 | 0.88 | NPC1 (0.64) | NPC1CNR1ALDH1A1TSHRRAB9A | |
| SCHEMBL3423025 | 0.82 | PDK1 (0.55) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL3422257 | 0.81 | PDK1 (0.50) | PDK1PDK2PDK3PDK4NPC1 | |
| Trifluoroacetic Acid SCHEMBL29406683 | 0.81 | ALDH1A1 (0.51) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL5550330 | 0.80 | HDAC1 (0.67) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL9230108 | 0.78 | RAB9A (0.56) | NPC1ALDH1A1TSHRRAB9APOLB | |
| SCHEMBL3765919 | 0.78 | CA12 (0.59) | PDK1PDK2PDK3PDK4NPC1 | |
| SCHEMBL28945385 | 0.77 | ALDH1A1 (0.53) | NPC1HDAC1HDAC6CNR1ALDH1A1 | |
| SCHEMBL11390139 | 0.77 | ALDH1A1 (0.58) | NPC1ALDH1A1TSHRPOLBKMT2A | |
| SCHEMBL10778839 | 0.76 | SMN1; SMN2 (0.52) | NPC1TSHRRAB9APOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123509-A1 | Carboxamide derivatives | MERCK PATENT GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123509-A1 | Carboxamide derivatives | F11, F12, F2 | PDK1 213/4885PDK2 607/4885PDK3 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.