Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5155216 | 0.84 | MAOA (0.48) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5157543 | 0.83 | KDM4E (0.47) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5158471 | 0.82 | MAOA (0.45) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5158018 | 0.81 | MAOA (0.43) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5158461 | 0.80 | KMT2A (0.50) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5157388 | 0.80 | KDM4E (0.48) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5159722 | 0.78 | MAOA (0.43) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5158044 | 0.77 | TUBB4A (0.59) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5289407 | 0.75 | TUBB4A (0.68) | MAOAMAOBKDM4EMAPTALDH1A1 | |
| SCHEMBL5157286 | 0.74 | TUBB4A (0.64) | MAOAMAOBKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010044-A1 | 3-INDOLYLMETHYLENE DERIVATIVES WITH CYTOSTATIC ACTION | UNIVERSITAET REGENSBURG (DE) | 2007-01-25 | — | — | WO | disclosed |
| EP-1746087-A1 | Derivates of 3-indolylmethylene having cytostatic properties | Universitaet Regensburg (DE) | 2007-01-24 | — | — | EP | disclosed |