Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159464 | 0.82 | ATM (0.36) | PLGGPR119STSKDM4EPKM | |
| SCHEMBL5153000 | 0.81 | OPRD1 (0.42) | JAK2JAK1GPR119OPRD1ATM | |
| SCHEMBL5159359 | 0.80 | KDM1A (0.42) | JAK2JAK1OPRD1ATM | |
| SCHEMBL5156033 | 0.80 | KDM1A (0.42) | JAK2JAK1OPRD1ATM | |
| SCHEMBL5155901 | 0.80 | CETP (0.41) | JAK2JAK1GPR119CETP | |
| SCHEMBL3855631 | 0.79 | JAK2 (0.39) | JAK2JAK1PLGGPR119STS | |
| SCHEMBL5159126 | 0.78 | AGTR2 (0.42) | JAK2JAK1 | |
| SCHEMBL5157337 | 0.77 | JAK2 (0.38) | JAK2JAK1GPR119STSHSD11B1 | |
| SCHEMBL475536 | 0.73 | KLK7 (0.38) | JAK2JAK1GPR119OPRD1OPRK1 | |
| SCHEMBL5156671 | 0.71 | JAK2 (0.36) | JAK2JAK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |