Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5153000 | 0.85 | OPRD1 (0.42) | JAK2JAK1GPR119KMT2A | |
| SCHEMBL5159359 | 0.84 | KDM1A (0.42) | JAK2JAK1KMT2AL3MBTL1 | |
| SCHEMBL5156033 | 0.84 | KDM1A (0.42) | JAK2JAK1KMT2AL3MBTL1 | |
| SCHEMBL4360263 | 0.81 | CETP (0.40) | CETPJAK2JAK1GPR119KMT2A | |
| SCHEMBL5158541 | 0.80 | JAK2 (0.38) | CETPJAK2JAK1GPR119 | |
| SCHEMBL475536 | 0.77 | KLK7 (0.38) | JAK2JAK1GPR119KMT2A | |
| SCHEMBL5159126 | 0.76 | AGTR2 (0.42) | JAK2JAK1 | |
| SCHEMBL5157337 | 0.73 | JAK2 (0.38) | JAK2JAK1GPR119 | |
| SCHEMBL14311382 | 0.73 | RIPK1 (0.49) | CETPGPR119 | |
| SCHEMBL4356137 | 0.71 | L3MBTL1 (0.39) | CETPGPR119KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |