Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.50 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | F3 | P13726 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516050 | 1.00 | TRPM8 (0.58) | TRPM8CYP3A4HSPD1HSPE1KMT2A | |
| SCHEMBL10220933 | 0.91 | TRPM8 (0.69) | TRPM8MAPTF3TDP1NPC1 | |
| SCHEMBL515634 | 0.87 | TRPM8 (0.57) | TRPM8KMT2AMAPTF3MEN1 | |
| SCHEMBL515635 | 0.87 | TRPM8 (0.57) | TRPM8KMT2AMAPTF3MEN1 | |
| SCHEMBL12060510 | 0.85 | NPC1 (0.60) | TRPM8CYP3A4HSPD1HSPE1KMT2A | |
| SCHEMBL10220934 | 0.75 | TRPM8 (0.61) | TRPM8TDP1NPC1L3MBTL1ALDH1A1 | |
| SCHEMBL28050166 | 0.74 | NPC1 (0.57) | TRPM8KMT2AMAOBMAPTF3 | |
| SCHEMBL8721921 | 0.74 | TRPM8 (1.00) | TRPM8NPC1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL8721927 | 0.74 | TRPM8 (1.00) | TRPM8NPC1L3MBTL1ALDH1A1RAB9A | |
| SCHEMBL179788 | 0.73 | CA2 (0.43) | ALDH1A1CA12CA4CA6CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046739-B1 | SUBSTITUTED ANILINE DERIVATIVES | UCB BIOPHARMA SPRL (BE) | 2015-08-26 | — | — | EP | disclosed |
| US-8624022-B2 | Substituted aniline derivatives | UCB PHARMA, S.A. (BE) | 2014-01-07 | — | — | US | disclosed |
| US-20120029188-A1 | Substituted Aniline Derivatives | UCB PHARMA S.A. (BE) | 2012-02-02 | — | — | US | disclosed |
| US-8071582-B2 | Substituted aniline derivatives | UCB PHARMA S.A. (BE) | 2011-12-06 | — | — | US | disclosed |
| US-20110014271-A1 | Substituted Aniline Derivatives | UCB PHARMA S.A. (BE) | 2011-01-20 | — | — | US | disclosed |
| US-7678785-B2 | Substituted aniline derivatives | UCB PHARMA S.A. (BE) | 2010-03-16 | — | — | US | disclosed |
| EP-2046739-A1 | SUBSTITUTED ANILINE DERIVATIVES | UCB Pharma S.A. (BE) | 2009-04-15 | — | — | EP | disclosed |
| US-20080045497-A1 | SUBSTITUTED ANILINE DERIVATIVES | UCB PHARMA S.A. (BE) | 2008-02-21 | — | — | US | disclosed |
| WO-2008012524-A1 | SUBSTITUTED ANILINE DERIVATIVES | UCB PHARMA S.A. (BE) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029188-A1 | Substituted Aniline Derivatives | NAT1, DPM1, IL4I1 | TRPM8 4470/4885CYP3A4 41/4885HSPD1 952/4885 |
| US-20080045497-A1 | SUBSTITUTED ANILINE DERIVATIVES | DPM1, ERG28, IL4I1 | TRPM8 4349/4885CYP3A4 45/4885HSPD1 877/4885 |
| US-20110014271-A1 | Substituted Aniline Derivatives | NAT1, DPM1, IL4I1 | TRPM8 4470/4885CYP3A4 41/4885HSPD1 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.