SCHEMBL516052

SCHEMBL516052

O=C(Nc1ccccc1)C1CCCCN1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.58
POLB P06746 1/20 0.57
ULK1 O75385 1/20 0.54
SCN3A Q9NY46 2/20 0.50
GAA P10253 2/20 0.50
MAPT P10636 2/20 0.50
SCN9A Q15858 1/20 0.50
PSMB8 P28062 1/20 0.49
DPP4 P27487 2/20 0.49
MEN1 O00255 1/20 0.49
GFER P55789 1/20 0.49
KMT2A Q03164 1/20 0.49
CTSC P53634 2/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
TSHR P16473 1/20 0.48
RAB9A P51151 2/20 0.47
EPHX1 P07099 1/20 0.47
EPHX2 P34913 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13708499 1.00 HPGD (0.58) HPGDPOLBULK1SCN3AGAA
Hydrochloric Acid SCHEMBL3266984 0.98 HPGD (0.57) HPGDPOLBULK1SCN3AGAA
SCHEMBL9352214 0.95 HPGD (0.56) HPGDPOLBULK1SCN3AGAA
SCHEMBL2392383 0.95 HPGD (0.56) HPGDPOLBULK1SCN3AGAA
SCHEMBL2172641 0.95 HPGD (0.56) HPGDPOLBULK1SCN3AGAA
Hydrochloric Acid SCHEMBL4306381 0.94 SCN3A (0.56) HPGDPOLBULK1SCN3AGAA
SCHEMBL7072829 0.90 HPGD (0.56) HPGDPOLBGAAMAPTDPP4
SCHEMBL7072835 0.90 HPGD (0.56) HPGDPOLBGAAMAPTDPP4
SCHEMBL1752153 0.86 SCN3A (0.59) HPGDULK1SCN3AMAPTSCN9A
SCHEMBL17676961 0.86 SCN3A (0.59) HPGDULK1SCN3AMAPTSCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102093284-B Method for enriching piperidine-2-formanilide optically active compound YICHANG HUMANWELL PHARMACEUTICAL CO LTD 2013-05-08 CN claimed
CN-102093284-A Method for enriching piperidine-2-formanilide optically active compound YICHANG HUMANWELL PHARMACEUTICAL CO LTD 2011-06-15 CN claimed
US-5786484-A Racemization and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof CHIROSCIENCE LIMITED (GB) 1998-07-28 US claimed
CN-1168134-A Racemization process for the production of levobupivacaine and related piperidinecarboxanilide anaesthetics CHIROSCIENCE LTD (GB) 1997-12-17 CN claimed
EP-0804417-A1 RACEMISATION PROCESS FOR USE IN THE MANUFACTURE OF LEVOBUPIVACAINE AND RELATED PIPERIDINECARBOXANILIDE ANAESTHETIC AGENTS Chiroscience Limited (GB) 1997-11-05 EP claimed
EP-0782569-A1 RACEMISATION AND ASYMMETRIC TRANSFORMATION PROCESSES USED IN THE MANUFACTURE OF LEVOBUPIVACAINE AND ANALOGUES THEREOF CHIROSCIENCE LIMITED (GB) 1997-07-09 EP claimed
WO-1996022281-A1 RACEMISATION PROCESS FOR USE IN THE MANUFACTURE OF LEVOBUPIVACAINE AND RELATED PIPERIDINECARBOXANILIDE ANAESTHETIC AGENTS CHIROSCIENCE LIMITED (GB) 1996-07-25 WO claimed
WO-1996009290-A1 RACEMISATION AND ASYMMETRIC TRANSFORMATION PROCESSES USED IN THE MANUFACTURE OF LEVOBUPIVACAINE AND ANALOGUES THEREOF CHIROSCIENCE LIMITED (GB) 1996-03-28 WO claimed
EP-2068958-B1 MEDICAL DEVICE INCLUDING AN ANESTHETIC AND METHOD OF PREPARATION THEREOF COOK MEDICAL TECHNOLOGIES LLC (US) 2016-10-19 EP disclosed
CN-102093284-B Method for enriching piperidine-2-formanilide optically active compound YICHANG HUMANWELL PHARMACEUTICAL CO LTD 2013-05-08 CN disclosed
CN-102093284-B Method for enriching piperidine-2-formanilide optically active compound YICHANG HUMANWELL PHARMACEUTICAL CO LTD 2013-05-08 CN disclosed
CN-102093284-B Method for enriching piperidine-2-formanilide optically active compound YICHANG HUMANWELL PHARMACEUTICAL CO LTD 2013-05-08 CN disclosed
US-20120027819-A1 Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices ISCH ANDREW P (US) 2012-02-02 US disclosed
CN-102093284-A Method for enriching piperidine-2-formanilide optically active compound YICHANG HUMANWELL PHARMACEUTICAL CO LTD 2011-06-15 CN disclosed
WO-1996022281-A1 RACEMISATION PROCESS FOR USE IN THE MANUFACTURE OF LEVOBUPIVACAINE AND RELATED PIPERIDINECARBOXANILIDE ANAESTHETIC AGENTS CHIROSCIENCE LIMITED (GB) 1996-07-25 WO disclosed
WO-1996011181-A1 THE MANUFACTURE OF LEVOBUPIVACAINE AND ANALOGUES THEREOF FROM L-LYSINE CHIROSCIENCE LIMITED (GB) 1996-04-18 WO disclosed
WO-1996009290-A1 RACEMISATION AND ASYMMETRIC TRANSFORMATION PROCESSES USED IN THE MANUFACTURE OF LEVOBUPIVACAINE AND ANALOGUES THEREOF CHIROSCIENCE LIMITED (GB) 1996-03-28 WO disclosed
WO-1996009290-A1 RACEMISATION AND ASYMMETRIC TRANSFORMATION PROCESSES USED IN THE MANUFACTURE OF LEVOBUPIVACAINE AND ANALOGUES THEREOF CHIROSCIENCE LIMITED (GB) 1996-03-28 WO disclosed
EP-0674644-A1 HERBICIDAL IMIDAZOLONES AND A PROCESS FOR THEIR MANUFACTURE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-10-04 EP disclosed
WO-1995010277-A1 ANALGESIC AGENT AND ITS USE CHIROSCIENCE LIMITED (GB) 1995-04-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120027819-A1 Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices ATP6V1B1, ASIC1, FGF23 HPGD 459/4885POLB 3776/4885ULK1 3961/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.