Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162126 | 0.89 | KDM4C (0.38) | KDM4CKDM6BMTNR1BKDM4EABCB11 | |
| SCHEMBL5160829 | 0.86 | GHSR (0.38) | KDM4CKDM6BALDH1A1MAPTGHSR | |
| SCHEMBL6223687 | 0.86 | PLA2G7 (0.40) | KDM4CKDM6BMTNR1BGHSRRORC | |
| SCHEMBL5160843 | 0.83 | KDM4C (0.35) | KDM4CKDM6BMTNR1BGHSRRORC | |
| SCHEMBL5551732 | 0.81 | MTNR1B (0.50) | MTNR1BKDM4EABCB11ALDH1A1POLB | |
| SCHEMBL6225110 | 0.79 | TP53 (0.40) | KDM4CALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL6226195 | 0.78 | HRH3 (0.39) | KDM4CKDM6BMTNR1BHTR1AMEN1 | |
| SCHEMBL2121245 | 0.78 | DRD2 (0.38) | MTNR1B | |
| SCHEMBL6225384 | 0.78 | SMN1; SMN2 (0.40) | MTNR1BKDM4EABCB11ALDH1A1POLB | |
| SCHEMBL6225074 | 0.78 | HRH3 (0.39) | KDM4CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756094-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005123723-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-12-29 | — | — | WO | disclosed |