Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN1 | O60741 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 6/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160839 | 0.88 | DRD2 (0.53) | POLBNPC1RAB9ADRD2HTR1A | |
| SCHEMBL5160955 | 0.86 | HTR1A (0.60) | NPC1RAB9ADRD2HTR1AGAA | |
| SCHEMBL5160692 | 0.84 | HTR1A (0.59) | RAB9AHTR1AADRA1A | |
| SCHEMBL5160732 | 0.81 | NPC1 (0.51) | POLBNPC1RAB9ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL6664273 | 0.80 | NPC1 (0.49) | POLBNPC1RAB9ADRD2DRD4 | |
| SCHEMBL6662366 | 0.77 | NPC1 (0.52) | NPC1RAB9ADRD2HTR1AKMT2A | |
| SCHEMBL9313091 | 0.77 | ALDH1A1 (0.71) | POLBNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL29111414 | 0.77 | MTNR1A (0.65) | POLBNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL6111995 | 0.76 | DRD2 (0.42) | POLBDRD2HTR1AKMT2AMEN1 | |
| SCHEMBL7875925 | 0.76 | DRD2 (0.54) | POLBNPC1RAB9ADRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323229-B1 | COMPOUNDS ARE USEFUL PSYCHOTHERAPEUTICS AND ARE POTENT AGONISTS AND/OR ANTAGONISTS OF THE SEROTONIN 1A (5-HT 1A) AND/OR SEROTONIN 1D (5-HT 1D) FOR TREATMENT OF HYPERTENSION, DEPRESSION, GENERALIZED ANXIETY DISORDER | PFIZER INC | 2001-11-27 | — | — | US | claimed |
| EP-0952154-B1 | N-acyl and N-aroyl aralkyl amides | PFIZER PROD INC (US) | 2004-08-18 | — | — | EP | disclosed |
| US-6451803-B1 | N-acyl and n-aroyl aralkyl amides useful in treating seritonergic disorders | PFIZER INC | 2002-09-17 | — | — | US | disclosed |
| US-6323229-B1 | COMPOUNDS ARE USEFUL PSYCHOTHERAPEUTICS AND ARE POTENT AGONISTS AND/OR ANTAGONISTS OF THE SEROTONIN 1A (5-HT 1A) AND/OR SEROTONIN 1D (5-HT 1D) FOR TREATMENT OF HYPERTENSION, DEPRESSION, GENERALIZED ANXIETY DISORDER | PFIZER INC | 2001-11-27 | — | — | US | disclosed |
| US-6197773-B1 | HEADACHES; ANTIDEPRESSANTS | PFIZER INC | 2001-03-06 | — | — | US | disclosed |