SCHEMBL5162228

SCHEMBL5162228

N#Cc1cccc(NC(=O)Cc2cc(O)ccc2N)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.60
ALDH1A1 P00352 5/20 0.54
DUSP3 P51452 1/20 0.54
KMT2A Q03164 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
MAPK1 P28482 1/20 0.50
HSD17B10 Q99714 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
TSHR P16473 1/20 0.49
ANO1 Q5XXA6 1/20 0.48
MEN1 O00255 1/20 0.48
MAPT P10636 1/20 0.48
ESRRG P62508 1/20 0.46
IDO1 P14902 1/20 0.45
HTT P42858 1/20 0.44
CCR3 P51677 1/20 0.44
NPC1 O15118 1/20 0.44
NFKB1 P19838 1/20 0.44
RAB9A P51151 1/20 0.44
NFKB2 Q00653 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5159761 0.86 IDO1 (0.47) LMNAALDH1A1KMT2AMAPK1TSHR
SCHEMBL5164495 0.86 NLRP3 (0.56) ALDH1A1KMT2AMEN1
Ammonia Solution, Strong SCHEMBL5163148 0.84 NLRP3 (0.55) ALDH1A1KMT2AMEN1MAPTRAB9A
SCHEMBL3815239 0.82 CYP1A2 (0.53) LMNAKMT2AL3MBTL1MEN1
SCHEMBL5164017 0.81 LMNA (0.61) LMNAALDH1A1DUSP3KMT2ASMN1; SMN2
SCHEMBL5162730 0.81 KCNJ5 (0.61) LMNAALDH1A1KMT2AHSD17B10L3MBTL1
SCHEMBL5159531 0.81 NLRP3 (0.54) ALDH1A1KMT2ASMN1; SMN2ANO1MEN1
SCHEMBL5159570 0.81 KMT2A (0.57) ALDH1A1KMT2ASMN1; SMN2ANO1MEN1
SCHEMBL5165552 0.81 NLRP3 (0.54) ALDH1A1KMT2ASMN1; SMN2MAPK1HSD17B10
SCHEMBL5162086 0.79 ALDH1A1 (0.61) ALDH1A1KMT2ASMN1; SMN2L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070067922-A1 4-Aminophenol derivatives and colorants comprising these compounds PROCTER & GAMBLE COMPANY, THE 2007-03-29 US claimed
EP-1762218-A1 4-aminophenol derivatives and colorants comprising these compounds Wella Aktiengesellschaft (DE) 2007-03-14 EP claimed
WO-2007026313-A2 4-AMINOPHENOL DERIVATIVES AND COLORANTS COMPRISING THESE COMPOUNDS THE PROCTER & GAMBLE COMPANY (US) 2007-03-08 WO claimed
US-20070067922-A1 4-Aminophenol derivatives and colorants comprising these compounds PROCTER & GAMBLE COMPANY, THE 2007-03-29 US disclosed
EP-1762218-A1 4-aminophenol derivatives and colorants comprising these compounds Wella Aktiengesellschaft (DE) 2007-03-14 EP disclosed
WO-2007026313-A2 4-AMINOPHENOL DERIVATIVES AND COLORANTS COMPRISING THESE COMPOUNDS THE PROCTER & GAMBLE COMPANY (US) 2007-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070067922-A1 4-Aminophenol derivatives and colorants comprising these compounds KRT18, S100A4, CKAP4 LMNA 1433/4885ALDH1A1 309/4885DUSP3 3360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.