Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160652 | 0.80 | GPR84 (0.37) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL8954827 | 0.78 | FAAH (0.41) | NPC1RAB9AGPR84FFAR1ACE2 | |
| SCHEMBL5160084 | 0.76 | TSHR (0.37) | GPR84FFAR1 | |
| SCHEMBL10615777 | 0.76 | CA2 (0.43) | NPC1RAB9AMAPTCA2MAPK1 | |
| SCHEMBL30186020 | 0.76 | FAAH (0.41) | FFAR1MAPTPPARDMMP2 | |
| SCHEMBL10617270 | 0.76 | NPC1 (0.41) | NPC1RAB9ACA2MAPK1MMP2 | |
| SCHEMBL5160556 | 0.76 | NAAA (0.43) | NPC1GPR84FFAR1MAPTLCK | |
| SCHEMBL5158364 | 0.76 | HCAR2 (0.36) | GPR84FFAR1MAPTLCKPPARD | |
| SCHEMBL5162497 | 0.75 | MMP2 (0.34) | NPC1RAB9ACA2MAPK1MMP2 | |
| SCHEMBL5163183 | 0.75 | HRH3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340746-B1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | SALTIGO GMBH (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1340746-A1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | BAYER AG (DE) | 2003-09-03 | — | — | EP | disclosed |