Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | ATIC | P31939 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 3/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31414101 | 1.00 | HSD17B10 (0.54) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL27572021 | 0.93 | HSD17B10 (0.48) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL28261469 | 0.90 | DHODH (0.52) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL344711 | 0.90 | HSD17B10 (0.50) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL901598 | 0.88 | HSD17B10 (0.48) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL2477681 | 0.87 | HSD17B10 (0.58) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL7537511 | 0.85 | DHODH (0.52) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL29291851 | 0.84 | HMGB1 (0.46) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL5162563 | 0.84 | PDE10A (0.50) | HSD17B10HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL29260803 | 0.84 | DHODH (0.55) | HSD17B10HPGDKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318523-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED | 2009-12-24 | — | — | US | disclosed |
| WO-2008012347-A1 | BENZO [F] ISOINDOLES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318523-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS | PTGER4, PTGER3, HTR4 | HSD17B10 2593/4885HPGD 732/4885KDM4E 1532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.