Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.46 |
| ▸ | LIG1 | P18858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25234080 | 0.85 | HNF4A (0.51) | HPGDKDM4ESMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL10934521 | 0.83 | ALDH1A1 (0.52) | HPGDKDM4ESMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL11664153 | 0.82 | ALDH1A1 (0.58) | HPGDKDM4ESMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL25265133 | 0.81 | LIG1 (0.41) | HPGDKDM4ESMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL9715736 | 0.81 | HPGD (0.48) | HPGDKDM4ESMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL967919 | 0.81 | CES2 (0.64) | HPGDKDM4ESMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL761381 | 0.78 | CES2 (0.65) | HPGDSMN1; SMN2ALDH1A1CA12CA1 | |
| SCHEMBL9797513 | 0.78 | KDM4E (0.67) | HPGDKDM4ESMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL29861559 | 0.78 | KDM4E (0.67) | HPGDKDM4ESMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL928902 | 0.77 | KDM4E (0.60) | HPGDKDM4ESMN1; SMN2ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473606-B1 | Controlling transgene expression across the skin | ETH ZUERICH (CH) | 2016-06-29 | — | — | EP | disclosed |
| US-8653046-B2 | Controlling transgene expression across the skin | ETH ZURICH (CH) | 2014-02-18 | — | — | US | disclosed |
| EP-2473606-A1 | CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN | ETH Zurich (CH) | 2012-07-11 | — | — | EP | disclosed |
| US-20120029074-A1 | CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN | ETH ZURICH (CH) | 2012-02-02 | — | — | US | disclosed |
| WO-2010115583-A1 | CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN | ETH ZURICH (CH) | 2010-10-14 | — | — | WO | disclosed |
| EP-2239326-A1 | Controlling transgene expression across the skin | ETH Zurich (CH) | 2010-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029074-A1 | CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN | REL, CUTA, PTAR1 | HPGD 1799/4885KDM4E 794/4885SMN1; SMN2 4673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.