Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159300 | 0.84 | NPC1 (0.30) | — | |
| SCHEMBL5164166 | 0.82 | RAB9A (0.37) | — | |
| SCHEMBL5161599 | 0.77 | ALDH1A1 (0.35) | — | |
| SCHEMBL6653278 | 0.74 | KMT2A (0.32) | — | |
| SCHEMBL5159025 | 0.74 | L3MBTL1 (0.45) | — | |
| SCHEMBL5165104 | 0.73 | — | — | |
| SCHEMBL290086 | 0.72 | ALDH1A1 (0.50) | CYP1A2HRH2HRH1HRH4 | |
| SCHEMBL5165151 | 0.72 | MAPK14 (0.40) | — | |
| SCHEMBL5159455 | 0.71 | ALDH1A1 (0.36) | — | |
| SCHEMBL5159460 | 0.70 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756098-A2 | 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005116025-A2 | 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2005-12-08 | — | — | WO | disclosed |