Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27736240 | 0.98 | L3MBTL1 (0.54) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL7825067 | 0.91 | ALDH1A1 (0.60) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL13198785 | 0.89 | ALDH1A1 (0.58) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL181005 | 0.86 | TSHR (0.56) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL11381303 | 0.84 | L3MBTL1 (0.54) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL6307398 | 0.84 | TSHR (0.54) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| Hydrochloric Acid SCHEMBL27539023 | 0.84 | TSHR (0.54) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL909586 | 0.84 | TSHR (0.54) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL28381532 | 0.82 | ALDH1A1 (0.49) | L3MBTL1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL10537657 | 0.82 | GAA (0.50) | L3MBTL1ALDH1A1HTTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106883148-A | A kind of restoring method of (2,6 dichloro-4,4 amido) a (4 ' chlorphenyl) benzene acetonitrile | 浙江国邦药业有限公司 | 2017-06-23 | — | — | CN | disclosed |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | 7TM PHARMA A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| EP-1758874-A1 | SUBSTITUTED THIAZOLEACETIC ACIDS AS CRTH2 LIGANDS | 7TM Pharma A/S (DK) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005116001-A1 | SUBSTITUTED THIAZOLEACETIC AS CRTH2 LIGANDS | 7TM PHARMA A/S (DK) | 2005-12-08 | — | — | WO | disclosed |
| EP-0712845-B1 | Amine compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-10-17 | — | — | EP | disclosed |
| EP-0679642-B1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-11-10 | — | — | EP | disclosed |
| US-5654296-A | HORMONE INHIBITOR; NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| WO-1997024325-A1 | DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |
| US-5633248-A | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS, DIARYLALKYLIDENEDIAMINES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-05-27 | — | — | US | disclosed |
| US-5607939-A | CALCIUM ANTAGONIST, GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONIST AND MONOAMINEU UPTAKE INHIBITORS FOR CENTRAL NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0712845-A1 | Amine compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-22 | — | — | EP | disclosed |
| EP-0679642-A1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-11-02 | — | — | EP | disclosed |
| EP-0445698-B1 | Thiocarbamoylacetonitrile compounds | MITSUBISHI CHEM IND (JP) | 1994-06-22 | — | — | EP | disclosed |
| US-5246958-A | Thiocarbamoylacetonitriles | MITSUBISHI KASEI CORPORATION (JP) | 1993-09-21 | — | — | US | disclosed |
| CN-1016687-B | PROCESS FOR PREPARATION OF ALPHA-ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2(3H)-Y1) BENZENE-ACETONITRILES | JANNSSEN PHARMACEUTICA N V (BE) | 1992-05-20 | — | — | CN | disclosed |
| EP-0445698-A1 | Thiocarbamoylacetonitrile compounds | MITSUBISHI KASEI CORPORATION (JP) | 1991-09-11 | — | — | EP | disclosed |
| CN-85105673-A | The method of preparation alpha-aromatic-4-(4,5-dihydro-3,5-dioxy-1,2,4-triazine-2 (3H) base)-benzyl cyanide | — | 1987-01-14 | — | — | CN | disclosed |
| US-4281141-A | FUNGICIDES | ELI LILLY AND COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| US-4009021-A | Imidazole plant growth regulators | ROHM AND HAAS COMPANY (US) | 1977-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119456-A1 | Substituted Thiazoleacetic Acid as Crth2 Ligands | HRH1, HRH2, HRH3 | L3MBTL1 3030/4885ALDH1A1 832/4885HTT 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.