Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | ALPG | P10696 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181005 | 0.97 | TSHR (0.56) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13198785 | 0.94 | ALDH1A1 (0.58) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6307398 | 0.94 | TSHR (0.54) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL27539023 | 0.94 | TSHR (0.54) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| Acetonitrile SCHEMBL28159901 | 0.90 | ALDH1A1 (0.55) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL28381532 | 0.87 | ALDH1A1 (0.49) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7995238 | 0.84 | SLC6A2 (0.58) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5164828 | 0.84 | L3MBTL1 (0.56) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5773518 | 0.84 | ALDH1A1 (0.50) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5052368 | 0.84 | ALDH1A1 (0.74) | TSHRTRPA1ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003808-A1 | OCTAHYDROQUINOLIZINES FOR ANTIDIABETIC TREATMENT | 55PHARMA DRUG DISCOVERY & DEVELOPMENT AG (AT) | 2011-01-06 | — | — | US | disclosed |
| EP-2222673-A1 | OCTAHYDROQUINOLI ZINES FOR ANTIDIABETIC TREATMENT | 55pharma Drug Discovery & Development AG (AT) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009076693-A1 | OCTAHYDROQUINOLI ZINES FOR ANTIDIABETIC TREATMENT | 55PHARMA DRUG DISCOVERY & DEVELOPMENT AG (AT) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003808-A1 | OCTAHYDROQUINOLIZINES FOR ANTIDIABETIC TREATMENT | GPR119, LIPC, GLP1R | TSHR 2069/4885TRPA1 2821/4885ALDH1A1 802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.