Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7259895 | 0.83 | HDAC1 (0.41) | NAMPTHDAC1CPB2GRIN2BGSK3B | |
| SCHEMBL7257280 | 0.81 | NAMPT (0.46) | NAMPTHDAC1GRIN2BGSK3BDYRK1A | |
| SCHEMBL7260124 | 0.79 | NAMPT (0.44) | NAMPTHDAC1CPB2GRIN2BGSK3B | |
| SCHEMBL2533910 | 0.79 | CPB2 (0.49) | CPB2ESR1ESR2 | |
| SCHEMBL7256357 | 0.78 | CPB2 (0.41) | NAMPTHDAC1CPB2GRIN2BGSK3B | |
| SCHEMBL14509382 | 0.78 | CPB2 (0.47) | CPB2 | |
| SCHEMBL31407652 | 0.78 | KLK5 (0.48) | NAMPTHDAC1GRIN2BITGA4ITGB7 | |
| SCHEMBL7257179 | 0.77 | GRIN2B (0.41) | NAMPTHDAC1GRIN2BSCN9AMEN1 | |
| SCHEMBL5465881 | 0.76 | CPB1 (0.47) | NAMPTHDAC1CPB2GRIN2B | |
| SCHEMBL7260258 | 0.76 | NAMPT (0.42) | NAMPTHDAC1GRIN2BGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710232-B2 | Imidazole derivatives used as TAFIa inhibitors | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2014-04-29 | — | — | US | disclosed |
| EP-1864979-A1 | Imidazole-derivatives as TAFAIa-inhibitors | Sanofi-Aventis Deutschland GmbH (DE) | 2007-12-12 | — | — | EP | disclosed |
| US-20070129341-A1 | IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-06-07 | — | — | US | disclosed |
| WO-2003013526-A1 | ANTICOAGULANT COMPOUNDS | MERCK & CO. INC. (US) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129341-A1 | IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS | TFPI, TFPI2, SERPINC1 | NAMPT 1982/4885HDAC1 149/4885CPB2 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.