Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL701084 | 0.84 | — | — | |
| SCHEMBL30237774 | 0.84 | — | — | |
| SCHEMBL2058115 | 0.80 | HIF1A (0.52) | CA9CA14HPGDHIF1AHSD17B10 | |
| SCHEMBL22396850 | 0.75 | ENPP2 (0.45) | HPGDHIF1AHSD17B10LMNAALDH1A1 | |
| SCHEMBL10423507 | 0.74 | ALDH1A1 (0.55) | CA9CA14CA3CA6CA5A | |
| Hydroquinone SCHEMBL28903112 | 0.74 | ENPP2 (0.65) | CA9CA14CA3CA5ACA5B | |
| Hydroquinone SCHEMBL575590 | 0.74 | ENPP2 (0.65) | CA9CA14CA3CA5ACA5B | |
| SCHEMBL13758572 | 0.72 | LMNA (0.44) | HPGDHIF1AHSD17B10LMNAPDK2 | |
| SCHEMBL28011329 | 0.71 | LMNA (0.43) | HPGDHIF1AHSD17B10LMNAPDK2 | |
| SCHEMBL1128576 | 0.71 | ENPP2 (0.45) | ENPP2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1766409-A2 | FLUORESCENT ISOTOPE TAGS AND THEIR METHOD OF USE | Molecular Probes, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006091214-A2 | FLUORESCENT ISOTOPE TAGS AND THEIR METHOD OF USE | MOLECULAR PROBES, INC. (US) | 2006-08-31 | — | — | WO | disclosed |