Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 7/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.45 |
| ▸ | HTR3B | O95264 | 2/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001737 | 0.81 | HRH4 (0.51) | HTR3AHRH4HTR3EHTR3BHTR3D | |
| SCHEMBL5168060 | 0.80 | KDM4E (0.48) | NCF1KDM4EALDH1A1 | |
| SCHEMBL8693928 | 0.80 | HRH4 (0.50) | HTR3AHRH4HTR3EHTR3BHTR3D | |
| SCHEMBL8082652 | 0.78 | HRH4 (0.48) | HTR3AHRH4HTR3EHTR3BHTR3D | |
| SCHEMBL5167771 | 0.74 | SIRT6 (0.52) | HRH4ALDH1A1HTR6 | |
| SCHEMBL3623865 | 0.72 | ADRA2C (0.62) | HTR3AHRH4ADRA2CNCF1HTR3E | |
| SCHEMBL29509033 | 0.72 | ADRA2C (0.62) | HTR3AHRH4ADRA2CNCF1HTR3E | |
| SCHEMBL22858428 | 0.72 | HTR3A (0.52) | HTR3AHRH4ADRA2CNCF1KDM4E | |
| SCHEMBL6002177 | 0.72 | HTR1A (0.62) | HTR3AHRH4ADRA2CNCF1HTR3E | |
| SCHEMBL5170379 | 0.71 | GAA (0.47) | HTR3AHRH4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007054836-A2 | 1, 2-SUBSTITUTED NAPHTHALENE DERIVATIVES WITH ANTIGLUTAMATERGIC PROPERTIES AND USES THEREOF | FAUST PHARMACEUTICALS (FR) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007054836-A2 | 1, 2-SUBSTITUTED NAPHTHALENE DERIVATIVES WITH ANTIGLUTAMATERGIC PROPERTIES AND USES THEREOF | FAUST PHARMACEUTICALS (FR) | 2007-05-18 | — | — | WO | disclosed |
| EP-1777219-A1 | 1,2-Substituted naphthalene derivatives with antiglutamatergic properties and uses thereof | Faust Pharmaceuticals (FR) | 2007-04-25 | — | — | EP | disclosed |
| EP-0701819-B1 | Novel compositions containing sertraline and a 5-HT1D receptor agonist or antagonist | PFIZER (US) | 2000-08-16 | — | — | EP | disclosed |