Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.48 |
| ▸ | HTR3A | P46098 | 6/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
| ▸ | HTR3B | O95264 | 2/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001737 | 0.79 | HRH4 (0.51) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8693928 | 0.78 | HRH4 (0.50) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5167342 | 0.78 | HTR3A (0.53) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5167771 | 0.72 | SIRT6 (0.52) | HRH4ALDH1A1 | |
| SCHEMBL6002177 | 0.69 | HTR1A (0.62) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL27359418 | 0.68 | HTR1A (0.61) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8692605 | 0.68 | HRH4 (0.50) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6305872 | 0.67 | HTR1A (0.59) | HTR3A | |
| SCHEMBL605232 | 0.65 | HRH4 (1.00) | HRH4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL17144774 | 0.65 | NCF1 (0.56) | HRH4HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701819-B1 | Novel compositions containing sertraline and a 5-HT1D receptor agonist or antagonist | PFIZER (US) | 2000-08-16 | — | — | EP | disclosed |