Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 3/20 | 0.52 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5167729 | 0.93 | HPGD (0.57) | HPGDALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL30599264 | 0.92 | HPGD (0.64) | HPGDALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL3258559 | 0.92 | HPGD (0.64) | HPGDALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL7905732 | 0.91 | PPARG (0.54) | HPGDALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL7905734 | 0.91 | PPARG (0.54) | HPGDALDH1A1SMN1; SMN2LMNAMAPT | |
| Hydrochloric Acid SCHEMBL5168951 | 0.90 | HPGD (0.62) | HPGDALDH1A1SMN1; SMN2LMNAMAPT | |
| Trifluoroacetic Acid SCHEMBL5180863 | 0.89 | HPGD (0.52) | HPGDALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL943063 | 0.80 | PPARG (0.58) | ALDH1A1SMN1; SMN2PPARGCYP3A4RXRA | |
| SCHEMBL1162595 | 0.79 | LMNA (0.63) | LMNAPPARGCYP3A4RXRACYP4F2 | |
| Pioglitazone SCHEMBL3862566 | 0.78 | PPARG (0.86) | HPGDALDH1A1MAPTPPARGCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694646-B1 | PROCESS FOR THE SYNTHESIS OF PIOGLITAZONE HYDROGEN CHLORIDE | RICHTER GEDEON VEGYESZET (HU) | 2007-04-25 | — | — | EP | disclosed |
| EP-1694646-A1 | PROCESS FOR THE SYNTHESIS OF PIOGLITAZONE HYDROGEN CHLORIDE | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058827-A1 | PROCESS FOR THE SYNTHESIS OF PIOGLITAZONE HYDROGEN CHLORIDE | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2005-06-30 | — | — | WO | disclosed |